Development of BOLD signal hemodynamic responses in the human brain

In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing...

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Fla.), 2012-11, Vol.63 (2), p.663-673
Main Authors:	Arichi, Tomoki, Fagiolo, Gianlorenzo, Varela, Marta, Melendez-Calderon, Alejandro, Allievi, Alessandro, Merchant, Nazakat, Tusor, Nora, Counsell, Serena J., Burdet, Etienne, Beckmann, Christian F., Edwards, A. David
Format:	Article
Language:	eng
Subjects:	Adult Age Babies Biomedical research Brain Brain - blood supply Brain - growth & development Brain development Female Functional MRI Hemodynamic response function Hemodynamics - physiology Humans Image Interpretation, Computer-Assisted - methods Infant Infant, Newborn Infant, Premature Intensive care Magnetic Resonance Imaging - methods Male Medical research Menstruation Middle Aged Neonate NMR Nuclear magnetic resonance Oxygen - blood Population Studies Young Adult
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Summary:	In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the Blood Oxygen Level Dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41+1weeks), and 10 preterm infants (median PMA 34+4weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond. ► First systematic characterization of the BOLD signal HRF in human neonates. ► A maturational trend in HRF morphology was identified. ► Application of empirical HRF models significantly improved neonatal fMRI analysis.
ISSN:	1053-8119 1095-9572