Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has n...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of experimental medicine 2012-09, Vol.209 (10), p.1723-1742
Main Authors: Weiss, Jonathan M, Bilate, Angelina M, Gobert, Michael, Ding, Yi, Curotto de Lafaille, Maria A, Parkhurst, Christopher N, Xiong, Huizhong, Dolpady, Jayashree, Frey, Alan B, Ruocco, Maria Grazia, Yang, Yi, Floess, Stefan, Huehn, Jochen, Oh, Soyoung, Li, Ming O, Niec, Rachel E, Rudensky, Alexander Y, Dustin, Michael L, Littman, Dan R, Lafaille, Juan J
Format: Article
Language:English
Subjects:
Animals
Cell Lineage
Cell Membrane - metabolism
Forkhead Transcription Factors - metabolism
Gene Expression Regulation - drug effects
Inflammation - immunology
Inflammation - metabolism
Intestines - immunology
Intestines - metabolism
Intestines - microbiology
Lymphocyte Activation - immunology
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - metabolism
Metagenome - immunology
Mice
Mice, Transgenic
Mucous Membrane - immunology
Mucous Membrane - metabolism
Neuropilin-1 - genetics
Neuropilin-1 - metabolism
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Thymus Gland - immunology
Thymus Gland - metabolism
Transforming Growth Factor beta - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20120914