An analysis of 8 cases of factor X deficiency

Background Factor X deficiency is a rare coagulation defect. There are occasional reports of factor X deficiency from India. Difficulty in accurate diagnosis and non-availability of ideal treatment is discussed. Methods Eight cases of factor X deficiency, diagnosed from 1992 to 2007 are reported her...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of hematology & blood transfusion 2008-03, Vol.24 (1), p.23-25
Main Authors: Shah, Nilam M., Patel, Ashwin P.
Format: Article
Language:English
Subjects:
Blood Transfusion Medicine
Hematology
Human Genetics
Medicine
Medicine & Public Health
Oncology
Original
Original Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Factor X deficiency is a rare coagulation defect. There are occasional reports of factor X deficiency from India. Difficulty in accurate diagnosis and non-availability of ideal treatment is discussed. Methods Eight cases of factor X deficiency, diagnosed from 1992 to 2007 are reported here Results Seven were male while one was female. Seven patients were symptomatic from early childhood. One patient became symptomatic from 18 years of age. Factor X assay was done in 4 patients, 3 had severe deficiency and one had mild deficiency. One patient had associated factor IX deficiency. Three patients had repeated bleeding episodes requiring multiple transfusions. Two patients had intracranial bleed and one had umbilical cord bleeding at birth. There was no mortality. No patient received prophylactic transfusion. Conclusions Factor X deficiency is a rare coagulation defect. Hereditary deficiency should be distinguished from acquired deficiency. CNS, joints and skin are the common sites of bleeding.
ISSN:0971-4502
0974-0449
0974-0449
0971-4502
DOI:10.1007/s12288-008-0018-7