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Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men
Objectives To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power. Design Prospective cohort. Setting Six U.S. academic medical centers. Participants Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (Mr...
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| Published in: | Journal of the American Geriatrics Society (JAGS) 2012-09, Vol.60 (9), p.1663-1672 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Snyder, Caryn K. Lapidus, Jodi A. Cawthon, Peggy M. Dam, Thuy-Tien L. Sakai, Lynn Y. Marshall, Lynn M. |
| description | Objectives
To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.
Design
Prospective cohort.
Setting
Six U.S. academic medical centers.
Participants
Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.
Measurements
Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two‐year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.
Results
Baseline serum albumin 3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.
Conclusion
Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men. |
| doi_str_mv | 10.1111/j.1532-5415.2012.04115.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3445747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1041141307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6695-51c00bd800257b5c6f26fa69b7a077566c2305c66ca18efdb4dfa493732fe66c3</originalsourceid><addsrcrecordid>eNqNkV1v0zAUhi0EYmXwF1AkhMTF0vnbyQVIUwWFaWVoHYI7y3GcNsV1hp2w7t9j0w8GN2BZ8vHx8x4f-wUgQ3CM4jhdjREjOGcUsTGGCI8hRTHcPACjw8FDMIIQ4rzgiB6BJyGsYCRhUTwGRxiXkPGSj0A1N35YZ2e2Gtaty-K8Mlb1beeyvssmS-UWJmVnQ9DWZDMVwsl-M--9cYt-eZIpV--Tn7pb45Pi0tYxmBn3FDxqlA3m2W49Bp_fvb2evM8vLqcfJmcXuea8ZDlDGsKqLmLPTFRM8wbzRvGyEgoKwTjXmMCY5lqhwjR1RetG0ZIIghsTs-QYvNnWvRmqtam1cb1XVt74dq38nexUK_88ce1SLrofklDKBBWxwKtdAd99H0zo5boN2lirnOmGIOPPE0yoQPjfaDKEIgJT1Rd_oatu8C7-RKIgL3HBaKSKLaV9F4I3zaFvBNPFSK5kslYma2XyXP7yXG6i9Pn9dx-Ee5Mj8HIHqKCVbbxyug2_OU4pZ2URuddb7ra15u6_G5Dn03mKoj7f6tvQm81Br_w3yQURTH75OJXsnHy9hryQV-Qn2InUYw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1040692854</pqid></control><display><type>article</type><title>Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men</title><source>Wiley Online Library</source><creator>Snyder, Caryn K. ; Lapidus, Jodi A. ; Cawthon, Peggy M. ; Dam, Thuy-Tien L. ; Sakai, Lynn Y. ; Marshall, Lynn M.</creator><creatorcontrib>Snyder, Caryn K. ; Lapidus, Jodi A. ; Cawthon, Peggy M. ; Dam, Thuy-Tien L. ; Sakai, Lynn Y. ; Marshall, Lynn M. ; Osteoporotic Fractures in Men (MrOS) Research Group</creatorcontrib><description>Objectives
To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.
Design
Prospective cohort.
Setting
Six U.S. academic medical centers.
Participants
Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.
Measurements
Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two‐year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.
Results
Baseline serum albumin <40 g/L was not associated with 2‐ or 4.6‐year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.
Conclusion
Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2012.04115.x</identifier><identifier>PMID: 22905696</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Absorptiometry, Photon ; Aged ; Aged, 80 and over ; aging ; albumin ; Biological and medical sciences ; Body Composition ; Chi-Square Distribution ; Elderly ; General aspects ; Hand Strength - physiology ; Humans ; Leg - physiology ; Linear Models ; Male ; Males ; Medical sciences ; Men ; Miscellaneous ; Muscle Strength - physiology ; Muscle, Skeletal - physiology ; Muscles ; Muscular system ; Older people ; Osteoporosis ; Prospective Studies ; Proteins ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; sarcopenia ; Serum Albumin - metabolism ; United States</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2012-09, Vol.60 (9), p.1663-1672</ispartof><rights>2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.</rights><rights>2012 American Geriatrics Society and Wiley Periodicals, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6695-51c00bd800257b5c6f26fa69b7a077566c2305c66ca18efdb4dfa493732fe66c3</citedby><cites>FETCH-LOGICAL-c6695-51c00bd800257b5c6f26fa69b7a077566c2305c66ca18efdb4dfa493732fe66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2012.04115.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2012.04115.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26446598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22905696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Snyder, Caryn K.</creatorcontrib><creatorcontrib>Lapidus, Jodi A.</creatorcontrib><creatorcontrib>Cawthon, Peggy M.</creatorcontrib><creatorcontrib>Dam, Thuy-Tien L.</creatorcontrib><creatorcontrib>Sakai, Lynn Y.</creatorcontrib><creatorcontrib>Marshall, Lynn M.</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Research Group</creatorcontrib><title>Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives
To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.
Design
Prospective cohort.
Setting
Six U.S. academic medical centers.
Participants
Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.
Measurements
Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two‐year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.
Results
Baseline serum albumin <40 g/L was not associated with 2‐ or 4.6‐year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.
Conclusion
Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>albumin</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Chi-Square Distribution</subject><subject>Elderly</subject><subject>General aspects</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Leg - physiology</subject><subject>Linear Models</subject><subject>Male</subject><subject>Males</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Miscellaneous</subject><subject>Muscle Strength - physiology</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscles</subject><subject>Muscular system</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk factors</subject><subject>sarcopenia</subject><subject>Serum Albumin - metabolism</subject><subject>United States</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkV1v0zAUhi0EYmXwF1AkhMTF0vnbyQVIUwWFaWVoHYI7y3GcNsV1hp2w7t9j0w8GN2BZ8vHx8x4f-wUgQ3CM4jhdjREjOGcUsTGGCI8hRTHcPACjw8FDMIIQ4rzgiB6BJyGsYCRhUTwGRxiXkPGSj0A1N35YZ2e2Gtaty-K8Mlb1beeyvssmS-UWJmVnQ9DWZDMVwsl-M--9cYt-eZIpV--Tn7pb45Pi0tYxmBn3FDxqlA3m2W49Bp_fvb2evM8vLqcfJmcXuea8ZDlDGsKqLmLPTFRM8wbzRvGyEgoKwTjXmMCY5lqhwjR1RetG0ZIIghsTs-QYvNnWvRmqtam1cb1XVt74dq38nexUK_88ce1SLrofklDKBBWxwKtdAd99H0zo5boN2lirnOmGIOPPE0yoQPjfaDKEIgJT1Rd_oatu8C7-RKIgL3HBaKSKLaV9F4I3zaFvBNPFSK5kslYma2XyXP7yXG6i9Pn9dx-Ee5Mj8HIHqKCVbbxyug2_OU4pZ2URuddb7ra15u6_G5Dn03mKoj7f6tvQm81Br_w3yQURTH75OJXsnHy9hryQV-Qn2InUYw</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Snyder, Caryn K.</creator><creator>Lapidus, Jodi A.</creator><creator>Cawthon, Peggy M.</creator><creator>Dam, Thuy-Tien L.</creator><creator>Sakai, Lynn Y.</creator><creator>Marshall, Lynn M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>201209</creationdate><title>Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men</title><author>Snyder, Caryn K. ; Lapidus, Jodi A. ; Cawthon, Peggy M. ; Dam, Thuy-Tien L. ; Sakai, Lynn Y. ; Marshall, Lynn M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6695-51c00bd800257b5c6f26fa69b7a077566c2305c66ca18efdb4dfa493732fe66c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorptiometry, Photon</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>albumin</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Chi-Square Distribution</topic><topic>Elderly</topic><topic>General aspects</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Leg - physiology</topic><topic>Linear Models</topic><topic>Male</topic><topic>Males</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Miscellaneous</topic><topic>Muscle Strength - physiology</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscles</topic><topic>Muscular system</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk factors</topic><topic>sarcopenia</topic><topic>Serum Albumin - metabolism</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snyder, Caryn K.</creatorcontrib><creatorcontrib>Lapidus, Jodi A.</creatorcontrib><creatorcontrib>Cawthon, Peggy M.</creatorcontrib><creatorcontrib>Dam, Thuy-Tien L.</creatorcontrib><creatorcontrib>Sakai, Lynn Y.</creatorcontrib><creatorcontrib>Marshall, Lynn M.</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Research Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snyder, Caryn K.</au><au>Lapidus, Jodi A.</au><au>Cawthon, Peggy M.</au><au>Dam, Thuy-Tien L.</au><au>Sakai, Lynn Y.</au><au>Marshall, Lynn M.</au><aucorp>Osteoporotic Fractures in Men (MrOS) Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2012-09</date><risdate>2012</risdate><volume>60</volume><issue>9</issue><spage>1663</spage><epage>1672</epage><pages>1663-1672</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><notes>National Institutes of Health - No. U01 AG027810; No. U01 AR45647</notes><notes>ark:/67375/WNG-5J3XT068-R</notes><notes>NIH Roadmap for Medical Research</notes><notes>The National Institute on Aging, the National Center for Research Resources</notes><notes>istex:27780349780452199406997BFA4BFD7F3D9767B1</notes><notes>The National Institute of Arthritis and Musculoskeletal and Skin Diseases</notes><notes>ArticleID:JGS4115</notes><notes>Shriners Hospitals for Children</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Objectives
To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.
Design
Prospective cohort.
Setting
Six U.S. academic medical centers.
Participants
Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.
Measurements
Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two‐year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.
Results
Baseline serum albumin <40 g/L was not associated with 2‐ or 4.6‐year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.
Conclusion
Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>22905696</pmid><doi>10.1111/j.1532-5415.2012.04115.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American Geriatrics Society (JAGS), 2012-09, Vol.60 (9), p.1663-1672 |
| issn | 0002-8614 1532-5415 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3445747 |
| source | Wiley Online Library |
| subjects | Absorptiometry, Photon Aged Aged, 80 and over aging albumin Biological and medical sciences Body Composition Chi-Square Distribution Elderly General aspects Hand Strength - physiology Humans Leg - physiology Linear Models Male Males Medical sciences Men Miscellaneous Muscle Strength - physiology Muscle, Skeletal - physiology Muscles Muscular system Older people Osteoporosis Prospective Studies Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Risk factors sarcopenia Serum Albumin - metabolism United States |
| title | Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men |
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