Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men

Objectives To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power. Design Prospective cohort. Setting Six U.S. academic medical centers. Participants Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (Mr...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2012-09, Vol.60 (9), p.1663-1672
Main Authors: Snyder, Caryn K., Lapidus, Jodi A., Cawthon, Peggy M., Dam, Thuy-Tien L., Sakai, Lynn Y., Marshall, Lynn M.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Aged
Aged, 80 and over
aging
albumin
Biological and medical sciences
Body Composition
Chi-Square Distribution
Elderly
General aspects
Hand Strength - physiology
Humans
Leg - physiology
Linear Models
Male
Males
Medical sciences
Men
Miscellaneous
Muscle Strength - physiology
Muscle, Skeletal - physiology
Muscles
Muscular system
Older people
Osteoporosis
Prospective Studies
Proteins
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk factors
sarcopenia
Serum Albumin - metabolism
United States
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Summary:Objectives To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power. Design Prospective cohort. Setting Six U.S. academic medical centers. Participants Community‐dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study. Measurements Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two‐year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants. Results Baseline serum albumin 3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration. Conclusion Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2012.04115.x