Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjögren's syndrome

Oral Diseases (2011) 18, 96–106 Objective:  Non‐obese diabetic (NOD) mice develop an autoimmune exocrinopathy that shows similarities with Sjögren’s syndrome. They provide an experimental model to study the pathoetiogenesis of this disease. Materials and Methods:  Salivary gland (SG) function and sa...

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Published in:Oral diseases 2012-01, Vol.18 (1), p.96-106
Main Authors: Roescher, N, Lodde, BM, Vosters, JL, Tak, PP, Catalan, MA, Illei, GG, Chiorini, JA
Format: Article
Language:English
Subjects:
Animals
autoimmune sialadenitis
B-Cell Activating Factor - biosynthesis
CD40 Antigens - biosynthesis
Cytokines - biosynthesis
Cytokines - blood
Dentistry
Disease Models, Animal
Female
immunology
Intercellular Adhesion Molecule-1 - biosynthesis
Intercellular Adhesion Molecule-1 - blood
Interleukins - biosynthesis
Interleukins - blood
Lymphocytes - immunology
Macrophages - immunology
Mice
Mice, Inbred NOD
Mice, Inbred Strains
non-obese diabetic mouse
Saliva - chemistry
Saliva - secretion
salivary gland
Salivary Glands - chemistry
Salivary Glands - pathology
Salivary Glands - physiopathology
Secretory Rate
Sialadenitis - pathology
Sialadenitis - physiopathology
Sjogren's Syndrome - etiology
Sjogren's Syndrome - immunology
Sjögren's syndrome
Sodium - analysis
Th1 Cells - immunology
Th2 Cells - immunology
Time Factors
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Summary:Oral Diseases (2011) 18, 96–106 Objective:  Non‐obese diabetic (NOD) mice develop an autoimmune exocrinopathy that shows similarities with Sjögren’s syndrome. They provide an experimental model to study the pathoetiogenesis of this disease. Materials and Methods:  Salivary gland (SG) function and salivary sodium content were measured in 8‐, 12‐, 16‐ and 20‐week‐old NOD and age‐matched CB6 mice. In NOD mice, SG expression of phenotypic cell markers, B cell‐stimulating and costimulatory molecules were evaluated. Cytokine levels were measured in serum and SG homogenates. Results:  Microscopically evident SG inflammation in NOD mice was preceded by expression of intercellular adhesion molecule 1 on epithelial cells in the presence of macrophages and relatively high levels of cytokines. Next, an influx consisting of mainly T, B, natural killer, plasma and dendritic cells was seen. Most cytokines, except for interleukin (IL)12/IL23p40 and B cell‐activating factor, decreased or remained stable over time, while glandular function deteriorated from 16 weeks of age onward compared with CB6 mice. Conclusion:  Sjögren’s syndrome‐like disease in NOD mice occurs in multiple stages; immunological and physiological abnormalities can be detected before focal inflammation appears and salivary output declines. Extrapolating this knowledge to human subjects could help in understanding the pathogenesis and aid the identification of potential therapeutic targets.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2011.01852.x