In vivo neuronal firing patterns during human epileptiform discharges replicated by electrical stimulation

Highlights ► The neuronal firing patterns during interictal epileptiform discharges (IEDs) and after single pulse electrical stimulation (SPES) can be described as burst-only, suppression-only, burst–suppression or no-change. ► Similar neuronal firing patterns can be observed during IEDs and after S...

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Bibliographic Details
Published in:Clinical neurophysiology 2012-09, Vol.123 (9), p.1736-1744
Main Authors: Alarcón, Gonzalo, Martinez, Juan, Kerai, Shashivadan V, Lacruz, Maria E, Quiroga, Rodrigo Quian, Selway, Richard P, Richardson, Mark P, García Seoane, Jorge J, Valentín, Antonio
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adult
Biological and medical sciences
Brain - pathology
Brain Waves - physiology
Cognitive ability
Electric Stimulation - methods
Electrical stimuli
Electrodes, Implanted
Electrodiagnosis. Electric activity recording
Electroencephalography - methods
Epilepsy
Epilepsy - pathology
Epilepsy - physiopathology
Epileptiform discharge
Extracellular recording
Female
Firing pattern
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Human
Humans
In vivo
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Nervous system
Nervous system (semeiology, syndromes)
Neurology
Neurons - physiology
Pathophysiology
Single pulse electrical stimulation
Single unit activity
SPES
Substance P
Young Adult
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Summary:Highlights ► The neuronal firing patterns during interictal epileptiform discharges (IEDs) and after single pulse electrical stimulation (SPES) can be described as burst-only, suppression-only, burst–suppression or no-change. ► Similar neuronal firing patterns can be observed during IEDs and after SPES. ► IEDs and responses to SPES appear to activate similar and generic cortical mechanisms, which may explain transient cognitive impairment.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2012.02.062