New insight into the role of NT-proBNP in alcoholic liver cirrhosis as a noninvasive marker of esophageal varices

To investigate the association between plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and formation of esophageal varices. Thirty-five patients with alcoholic cirrhosis were divided into three groups according to the Child-Pugh classification: grade A (n=11, 32%), B (...

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Bibliographic Details
Published in:Croatian medical journal 2012-08, Vol.53 (4), p.374-378
Main Authors: Ljubicić, Neven, Gomercić, Marija, Zekanović, Drazen, Bodrozić-Dzakić, Tomislava, Duzel, Ana
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Biological markers
Biomarkers - blood
Care and treatment
Diagnosis
Esophageal and Gastric Varices - blood
Esophageal and Gastric Varices - etiology
Esophageal varices
Female
Health aspects
Hemodynamics
Humans
Identification and classification
Liver cirrhosis
Liver Cirrhosis, Alcoholic - blood
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - physiopathology
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Natriuretic peptides
Peptide Fragments - blood
Sensitivity and Specificity
Severity of Illness Index
Short Communication
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Summary:To investigate the association between plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and formation of esophageal varices. Thirty-five patients with alcoholic cirrhosis were divided into three groups according to the Child-Pugh classification: grade A (n=11, 32%), B (n=12, 34%), and C (n=12, 34%). System hemodynamic parameters were measured using sphygmomanometry, electrocardiography, and echocardiography. NT-proBNP was analyzed by using an electrochemiluminiscence sandwich immunoassay. The presence of esophageal varices was associated with a higher serum NT-proBNP level, with a cut-off value of
ISSN:0353-9504
1332-8166
DOI:10.3325/cmj.2012.53.374