Influence of Alternanthera brasiliana (L.) Kuntze on Altered Antioxidant Enzyme Profile during Cutaneous Wound Healing in Immunocompromised Rats

Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) is a herbaceous plant used against inflammation, cough, and diarrhea in Brazilian popular medicine. In our preliminary study, promising wound healing activity of methanol extract of leaves of A. brasiliana (MEAB) was observed in normal excision an...

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Published in:ISRN pharmacology 2012, Vol.2012 (2012), p.1-8
Main Authors: Barua, Chandana Choudhury, Ara Begum, Shameem, Talukdar, Archana, Datta Roy, Jayanti, Buragohain, Bhaben, Chandra Pathak, Debesh, Kumar Sarma, Dilip, Saikia Bora, Rumi, Gupta, Asheesh
Format: Article
Language:English
Subjects:
Alternanthera brasiliana
Amaranthaceae
Angiogenesis
Antioxidants
Ascorbic acid
Basement membranes
Catalase
Collagen
Cough
Diarrhea
Drugs
Enzymes
Fibroblasts
Hydrocortisone
Hydroxyproline
Leaves
Medicinal plants
Methanol
Ointments
Rodents
Science
Superoxide dismutase
Wound healing
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Summary:Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) is a herbaceous plant used against inflammation, cough, and diarrhea in Brazilian popular medicine. In our preliminary study, promising wound healing activity of methanol extract of leaves of A. brasiliana (MEAB) was observed in normal excision and incision wound models. Therefore, the present study was designed to investigate the wound healing activity along with the antioxidant enzyme profile during cutaneous excision immunocompromised wound after topical application of 5% w/w ointment of MEAB in rats. Immunocompromised state was induced by pretreatment with hydrocortisone (HC) at 40 mg/kg body weight (i.m.) in male rats. Following one-week pretreatment with HC, wounds were created. The vehicle, 5% (w/w) ointment of MEAB, or standard drug (Himax) was applied topically twice daily. Healing potential was evaluated by the rate of wound contraction, estimation of enzymatic and nonenzymatic antioxidants like catalase, SOD, GSH, protein, vitamin C, and hydroxyproline content, which was supported by histopathological study on the 8th day following wounding. There was significant increase in the enzymatic and nonenzymatic antioxidant parameters in the extract-reated group as compared to control group. Histopathological study revealed collagen deposition, fibroblast proliferation, angiogenesis, and development of basement membrane in A. brasiliana group. The results of the present investigation revealed significant wound healing activity of MEAB.
ISSN:2090-5165
2090-5173
2090-5173
DOI:10.5402/2012/948792