Viral Etiology of Acute Febrile Respiratory Illnesses in Hospitalized Children Younger Than 24 Months

Background: Respiratory infections are a leading cause of pediatric hospitalizations. This study investigated whether virus—virus or virus—Bordetella co-infections are more frequent or more severe than previously recognized. Methods: This is a 3-year prospective study of children younger than 24 mon...

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Bibliographic Details
Published in:Clinical pediatrics 2011-06, Vol.50 (6), p.513-517
Main Authors: Suryadevara, Manika, Cummings, Erin, Bonville, Cynthia A., Bartholoma, Nadine, Riddell, Scott, Kiska, Deanna, Rosenberg, Helene F., Domachowske, Joseph B.
Format: Article
Language:English
Subjects:
Acute Disease
Bordetella
Child, Hospitalized
Comorbidity
Enterovirus
Enterovirus - genetics
Enterovirus - isolation & purification
Female
Fever - virology
Hospitalization
Humans
Infant
Infant, Newborn
Male
Nasopharynx - virology
Pediatrics
Polymerase Chain Reaction
Prospective Studies
Respiratory diseases
Respiratory syncytial virus
Respiratory Syncytial Viruses - genetics
Respiratory Syncytial Viruses - isolation & purification
Respiratory Tract Infections - physiopathology
Respiratory Tract Infections - virology
Rhinovirus
Rhinovirus - genetics
Rhinovirus - isolation & purification
Severity of Illness Index
Viral infections
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Summary:Background: Respiratory infections are a leading cause of pediatric hospitalizations. This study investigated whether virus—virus or virus—Bordetella co-infections are more frequent or more severe than previously recognized. Methods: This is a 3-year prospective study of children younger than 24 months hospitalized with a febrile respiratory illness. Viral pathogens were detected using multiplex polymerase chain reaction (PCR), enzyme-linked immunoassays, and/or viral cultures from nasopharyngeal samples. Bordetella infections were detected by PCR. Results: A total of 201 patients were enrolled. Respiratory viruses were detected in 187 (93%) patients, with 52 (28%) multipathogen infections. The most common viruses detected were respiratory syncytial virus and rhinovirus/enterovirus. There were no differences in illness severity when comparing patients infected with one pathogen and those with multipathogen infection. Conclusion: Virus co-infection in young children hospitalized with an acute febrile respiratory infection is common but does not appear to be associated with illness severity.
ISSN:0009-9228
1938-2707
DOI:10.1177/0009922810394834