Physiotherapy intervention in Parkinson’s disease: systematic review and meta-analysis

Objective To assess the effectiveness of physiotherapy compared with no intervention in patients with Parkinson’s disease.Design Systematic review and meta-analysis of randomised controlled trials.Data sources Literature databases, trial registries, journals, abstract books, and conference proceedin...

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Bibliographic Details
Published in:BMJ (Online) 2012-08, Vol.345 (7872), p.11-11
Main Authors: Tomlinson, Claire L, Patel, Smitaa, Meek, Charmaine, Herd, Clare P, Clarke, Carl E, Stowe, Rebecca, Shah, Laila, Sackley, Catherine, Deane, Katherine H O, Wheatley, Keith, Ives, Natalie
Format: Article
Language:English
Subjects:
Activities of Daily Living
Balance
Clinical outcomes
Clinical trials
Clinical Trials (Epidemiology)
Data processing
Disability Evaluation
Economic analysis
Evidence-based medicine
Experimentation
Female
Fitness equipment
Gait
Gait - physiology
Health Economics
Health outcomes
Health Policy
Health Service Research
Humans
Intervention
Male
Martial Arts
Meta-analysis
Movement disorders
Neurodegenerative diseases
Neurology
Online searching
Outcome Assessment, Health Care - statistics & numerical data
Parkinson disease
Parkinson Disease - physiopathology
Parkinson Disease - rehabilitation
Parkinson's disease
Patients
Physical therapy
Physical Therapy Modalities
Physiotherapy
Quality of Life
Randomized Controlled Trials as Topic
Rehabilitation
Sociology
Sports and Exercise Medicine
Systematic review
Treadmills
Walking
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Summary:Objective To assess the effectiveness of physiotherapy compared with no intervention in patients with Parkinson’s disease.Design Systematic review and meta-analysis of randomised controlled trials.Data sources Literature databases, trial registries, journals, abstract books, and conference proceedings, and reference lists, searched up to the end of January 2012.Review methods Randomised controlled trials comparing physiotherapy with no intervention in patients with Parkinson’s disease were eligible. Two authors independently abstracted data from each trial. Standard meta-analysis methods were used to assess the effectiveness of physiotherapy compared with no intervention. Tests for heterogeneity were used to assess for differences in treatment effect across different physiotherapy interventions used. Outcome measures were gait, functional mobility and balance, falls, clinician rated impairment and disability measures, patient rated quality of life, adverse events, compliance, and economic analysis outcomes.Results 39 trials of 1827 participants met the inclusion criteria, of which 29 trials provided data for the meta-analyses. Significant benefit from physiotherapy was reported for nine of 18 outcomes assessed. Outcomes which may be clinically significant were speed (0.04 m/s, 95% confidence interval 0.02 to 0.06, P
ISSN:0959-8138
1756-1833
0959-8146
1756-1833
DOI:10.1136/bmj.e5004