Mechanism of the sex difference in neuronal ischemic cell death

Highlights ► We examine the effects of in vitro ischemia on cultured neurons. ► Cultured neurons from female brain are more resistant to in vitro ischemia than neurons from males. ► Neurons from females have less sEH expression than those from males at baseline. ► Knockout of the gene encoding sEH e...

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Bibliographic Details
Published in:Neuroscience 2012-09, Vol.219, p.183-191
Main Authors: Fairbanks, S.L, Young, J.M, Nelson, J.W, Davis, C.M, Koerner, I.P, Alkayed, N.J
Format: Article
Language:English
Subjects:
acute stroke
Animals
Biological and medical sciences
brain ischemia
Brain Ischemia - enzymology
Brain Ischemia - pathology
Cell Death - physiology
Chromatography, Liquid
EETs
Epoxide Hydrolases - metabolism
Female
Fundamental and applied biological sciences. Psychology
gender
Immunohistochemistry
Male
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurology
Neurons - enzymology
Neurons - pathology
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Sex Characteristics
soluble epoxide hydrolase
Stroke - enzymology
Stroke - pathology
Tandem Mass Spectrometry
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Highlights ► We examine the effects of in vitro ischemia on cultured neurons. ► Cultured neurons from female brain are more resistant to in vitro ischemia than neurons from males. ► Neurons from females have less sEH expression than those from males at baseline. ► Knockout of the gene encoding sEH eradicates the sex difference in wild-type neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.05.048