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DNA sequence of the control region of phage D108: the N-terminal amino acid sequences of repressor and transposase are similar both in phage D108 and in its relative, phage Mu
We have determined the DNA sequence of the control region of phage D108 up to position 1419 at the left end of the phage genome. Open reading frames for the repressor gene, ner gene, and the 5' part of the A gene (which codes for transposase) are found in the sequence. The genetic organization...
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| Published in: | Nucleic acids research 1986-05, Vol.14 (9), p.3813-3825 |
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| Language: | English |
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| container_end_page | 3825 |
| container_issue | 9 |
| container_start_page | 3813 |
| container_title | Nucleic acids research |
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| creator | Mizuuchi, Michiyo Weiberg, Robert A. Mizuuchi, Kiyoshi |
| description | We have determined the DNA sequence of the control region of phage D108 up to position 1419 at the left end of the phage genome. Open reading frames for the repressor gene, ner gene, and the 5' part of the A gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino acid sequences of the regulatory proteins of the two phages. The N-terminal amino acid sequences of the transposases of the two phages also share only limited homology. On the other hand, a significant amino acid sequence homology was found within each phage between the N-terminal parts of the repressor and transposase. We propose that the N-terminal domains of the repressor and transposase of each phage interact functionally in the process of making the decision between the lytic and the lysogenic mode of growth. |
| doi_str_mv | 10.1093/nar/14.9.3813 |
| format | article |
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Open reading frames for the repressor gene, ner gene, and the 5' part of the A gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino acid sequences of the regulatory proteins of the two phages. The N-terminal amino acid sequences of the transposases of the two phages also share only limited homology. On the other hand, a significant amino acid sequence homology was found within each phage between the N-terminal parts of the repressor and transposase. We propose that the N-terminal domains of the repressor and transposase of each phage interact functionally in the process of making the decision between the lytic and the lysogenic mode of growth.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/14.9.3813</identifier><identifier>PMID: 3012481</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Amino Acid Sequence ; Biological and medical sciences ; Coliphages - genetics ; DNA Transposable Elements ; DNA, Viral - genetics ; Fundamental and applied biological sciences. Psychology ; Gene expression ; genes ; Genes, Regulator ; Genes, Viral ; Molecular and cellular biology ; Molecular genetics ; nucleotide sequence ; Nucleotidyltransferases - genetics ; phage D108 ; Phage Mu ; Repressor Proteins - genetics ; repressors ; Sequence Homology, Nucleic Acid ; Transcription Factors - genetics ; Transposases ; transposonase</subject><ispartof>Nucleic acids research, 1986-05, Vol.14 (9), p.3813-3825</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-1b6927c17642cb65ed6a949b5d0224bd0f9e14561cb6a674a3274c2b2cfe8cb53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC339817/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC339817/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8758863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3012481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizuuchi, Michiyo</creatorcontrib><creatorcontrib>Weiberg, Robert A.</creatorcontrib><creatorcontrib>Mizuuchi, Kiyoshi</creatorcontrib><title>DNA sequence of the control region of phage D108: the N-terminal amino acid sequences of repressor and transposase are similar both in phage D108 and in its relative, phage Mu</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>We have determined the DNA sequence of the control region of phage D108 up to position 1419 at the left end of the phage genome. Open reading frames for the repressor gene, ner gene, and the 5' part of the A gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino acid sequences of the regulatory proteins of the two phages. The N-terminal amino acid sequences of the transposases of the two phages also share only limited homology. On the other hand, a significant amino acid sequence homology was found within each phage between the N-terminal parts of the repressor and transposase. We propose that the N-terminal domains of the repressor and transposase of each phage interact functionally in the process of making the decision between the lytic and the lysogenic mode of growth.</description><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>Coliphages - genetics</subject><subject>DNA Transposable Elements</subject><subject>DNA, Viral - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>genes</subject><subject>Genes, Regulator</subject><subject>Genes, Viral</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>nucleotide sequence</subject><subject>Nucleotidyltransferases - genetics</subject><subject>phage D108</subject><subject>Phage Mu</subject><subject>Repressor Proteins - genetics</subject><subject>repressors</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transcription Factors - genetics</subject><subject>Transposases</subject><subject>transposonase</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqFkk1vEzEQhlcIVELhyBHJB8SJTf1tLxKHqoUWqRQJAUJcrFnvbGLYrIO9qeBX8Rdx2iiUU08jzfvMh8dvVT1ldM5oI45GSEdMzpu5sEzcq2ZMaF7LRvP71YwKqmpGpX1YPcr5O6VMMiUPqgNBGZeWzao_p5fHJOPPDY4eSezJtETi4zilOJCEixDHbXa9hAWSU0btq2visp4wrcIIA4ESIgEfun2fvC1JuE6Yc0wExo5MCca8jhkyEkhIcliFARJp47QkYbw14BovmTDl0mOAKVzhy53-fvO4etDDkPHJLh5Wn9---XRyXl98OHt3cnxRe8XoVLNWN9x4ZrTkvtUKOw2NbFrVUc5l29G-QSaVZkUEbSQIbqTnLfc9Wt8qcVi9vum73rQr7DyWi8Dg1imsIP12EYL7XxnD0i3ilROiscyU-he7-hTLUfLkViF7HAYYMW6yM9qaxgp1J8gaoTWn_G5QasWpsQWsb0CfYs4J-_3WjLqtZVyxTMFd47aWKfyz20_d0zuPFP35TofsYejLT_qQ95g1ylot_o0NecJfexnSD6eNMMqdf_3mKNPio1Bf3Jn4C2wl2cM</recordid><startdate>19860512</startdate><enddate>19860512</enddate><creator>Mizuuchi, Michiyo</creator><creator>Weiberg, Robert A.</creator><creator>Mizuuchi, Kiyoshi</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860512</creationdate><title>DNA sequence of the control region of phage D108: the N-terminal amino acid sequences of repressor and transposase are similar both in phage D108 and in its relative, phage Mu</title><author>Mizuuchi, Michiyo ; Weiberg, Robert A. ; Mizuuchi, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-1b6927c17642cb65ed6a949b5d0224bd0f9e14561cb6a674a3274c2b2cfe8cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Coliphages - genetics</topic><topic>DNA Transposable Elements</topic><topic>DNA, Viral - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>genes</topic><topic>Genes, Regulator</topic><topic>Genes, Viral</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>nucleotide sequence</topic><topic>Nucleotidyltransferases - genetics</topic><topic>phage D108</topic><topic>Phage Mu</topic><topic>Repressor Proteins - genetics</topic><topic>repressors</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcription Factors - genetics</topic><topic>Transposases</topic><topic>transposonase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuuchi, Michiyo</creatorcontrib><creatorcontrib>Weiberg, Robert A.</creatorcontrib><creatorcontrib>Mizuuchi, Kiyoshi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuuchi, Michiyo</au><au>Weiberg, Robert A.</au><au>Mizuuchi, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA sequence of the control region of phage D108: the N-terminal amino acid sequences of repressor and transposase are similar both in phage D108 and in its relative, phage Mu</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1986-05-12</date><risdate>1986</risdate><volume>14</volume><issue>9</issue><spage>3813</spage><epage>3825</epage><pages>3813-3825</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><notes>ark:/67375/HXZ-0163R35V-G</notes><notes>ArticleID:14.9.3813</notes><notes>istex:0E619319A0F384D9C13DFC178EE4980D23B17CB3</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>We have determined the DNA sequence of the control region of phage D108 up to position 1419 at the left end of the phage genome. Open reading frames for the repressor gene, ner gene, and the 5' part of the A gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino acid sequences of the regulatory proteins of the two phages. The N-terminal amino acid sequences of the transposases of the two phages also share only limited homology. On the other hand, a significant amino acid sequence homology was found within each phage between the N-terminal parts of the repressor and transposase. We propose that the N-terminal domains of the repressor and transposase of each phage interact functionally in the process of making the decision between the lytic and the lysogenic mode of growth.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3012481</pmid><doi>10.1093/nar/14.9.3813</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nucleic acids research, 1986-05, Vol.14 (9), p.3813-3825 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_339817 |
| source | PubMed Central; Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Amino Acid Sequence Biological and medical sciences Coliphages - genetics DNA Transposable Elements DNA, Viral - genetics Fundamental and applied biological sciences. Psychology Gene expression genes Genes, Regulator Genes, Viral Molecular and cellular biology Molecular genetics nucleotide sequence Nucleotidyltransferases - genetics phage D108 Phage Mu Repressor Proteins - genetics repressors Sequence Homology, Nucleic Acid Transcription Factors - genetics Transposases transposonase |
| title | DNA sequence of the control region of phage D108: the N-terminal amino acid sequences of repressor and transposase are similar both in phage D108 and in its relative, phage Mu |
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