Fibroblast Growth Factor 23 and Inflammation in CKD

Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD. The association between levels of FGF23 and th...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2012-07, Vol.7 (7), p.1155-1162
Main Authors: Munoz Mendoza, Jair, Isakova, Tamara, Ricardo, Ana C, Xie, Huiliang, Navaneethan, Sankar D, Anderson, Amanda H, Bazzano, Lydia A, Xie, Dawei, Kretzler, Matthias, Nessel, Lisa, Hamm, L Lee, Negrea, Lavinia, Leonard, Mary B, Raj, Dominic, Wolf, Myles
Format: Article
Language:English
Subjects:
C-Reactive Protein - analysis
Cross-Sectional Studies
Female
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - physiology
Humans
Inflammation - blood
Inflammation - etiology
Male
Middle Aged
Original
Prospective Studies
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
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Summary:Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD. The association between levels of FGF23 and the inflammatory markers IL-6, C-reactive protein (CRP), TNF-α, and fibrinogen was assessed in a cross-sectional analysis of 3879 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study between June 2003 and September 2008. FGF23 correlated directly with IL-6 (r=0.4), CRP (r=0.2), TNF-α (r=0.4), and fibrinogen (r=0.3; P
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.13281211