Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated. RBL-2H3 (rat basophilic leukemia) cells were incubated with these compounds, and the release of β-hexosaminidase and cytotoxicity w...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2012-05, Vol.64 (3), p.349-356
Main Authors: Yamada, Parida, Ono, Takako, Shigemori, Hideyuki, Han, Junkyu, Isoda, Hiroko
Format: Article
Language:English
Subjects:
Allergic diseases
Allergies
Antigens
Basophilic leukemia
Biochemistry
Biological and medical sciences
Biomedicine
Biotechnology
Carpinus
Chemistry
Chemistry and Materials Science
Cytotoxicity
Degranulation
Fundamental and applied biological sciences. Psychology
Galls
Histamine
Original Research
Oxidation
Tannins
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Summary:In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated. RBL-2H3 (rat basophilic leukemia) cells were incubated with these compounds, and the release of β-hexosaminidase and cytotoxicity were measured. Of the thirteen tannins, tetragalloylglucose ( 2 ), pentagalloylglucose ( 3 ), casuarictin ( 4 ), and casuarinin ( 9 ) were the most potent inhibitors, and all the tannins showed no cytotoxic effect after 24 h of incubation. The results obtained suggest that tannins from C. tschonoskii are capable of inhibiting allergic reactions and may be useful for the treatment or prevention of type I allergic diseases.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-012-9457-y