Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐der...

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Bibliographic Details
Published in:EMBO molecular medicine 2011-12, Vol.3 (12), p.742-754
Main Authors: Kuwabara, Tomoko, Kagalwala, Mohamedi N., Onuma, Yasuko, Ito, Yuzuru, Warashina, Masaki, Terashima, Kazuyuki, Sanosaka, Tsukasa, Nakashima, Kinichi, Gage, Fred H., Asashima, Makoto
Format: Article
Language:English
Subjects:
Animals
Beta2 protein
Biosynthesis
Diabetes
Diabetes mellitus
Experiments
Female
Gene expression
Gene Expression Profiling
Hippocampus
Hippocampus - cytology
Insulin
Insulin - biosynthesis
Insulin resistance
Mammals
Mice
Mice, Inbred C57BL
neural stem cell
Neural stem cells
Neural Stem Cells - metabolism
Neurogenesis
Neurons
Olfactory bulb
Olfactory Bulb - cytology
Pancreas
Pancreas transplantation
Paracrine signalling
Rats
Stem cell transplantation
Stem cells
Transcription factors
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Summary:In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP‐4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin‐producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes. See accompanying article http://dx.doi.org/10.1002/emmm.201100178
ISSN:1757-4676
1757-4684
DOI:10.1002/emmm.201100177