A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia

KCNN3, encoding the small conductance calcium‐activated potassium channel SK3, harbours a polymorphic CAG repeat in the amino‐terminal coding region with yet unproven function. Hypothesizing that KCNN3 genotypes do not influence susceptibility to schizophrenia but modify its phenotype, we explored t...

Full description

Saved in:
Bibliographic Details
Published in:EMBO molecular medicine 2011-06, Vol.3 (6), p.309-319
Main Authors: Grube, Sabrina, Gerchen, Martin F., Adamcio, Bartosz, Pardo, Luis A., Martin, Sabine, Malzahn, Dörthe, Papiol, Sergi, Begemann, Martin, Ribbe, Katja, Friedrichs, Heidi, Radyushkin, Konstantin A, Müller, Michael, Benseler, Fritz, Riggert, Joachim, Falkai, Peter, Bickeböller, Heike, Nave, Klaus‐Armin, Brose, Nils, Stühmer, Walter, Ehrenreich, Hannelore
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Animals
Base Sequence
Brain research
Calcium conductance
Case-Control Studies
Cell Line
Cognition & reasoning
Cognition - physiology
Cognitive ability
Data analysis
Data collection
Drug dosages
Female
Gene Frequency
Gene polymorphism
Genes
Genotype
Genotype & phenotype
higher cognitive testing
Humans
Male
Mental disorders
Mice
Middle Aged
mouse behaviour
Neural coding
neuropsychology
Patch-Clamp Techniques
Phenotype
Phenotypes
Polyglutamine
Polymorphism, Genetic
Potassium channels (calcium-gated)
Potassium conductance
Schizophrenia
Schizophrenia - genetics
small conductance calcium‐activated potassium channel
Small-Conductance Calcium-Activated Potassium Channels - genetics
Small-Conductance Calcium-Activated Potassium Channels - metabolism
Software
Trinucleotide repeats
Trinucleotide Repeats - genetics
whole‐cell patch clamp
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:KCNN3, encoding the small conductance calcium‐activated potassium channel SK3, harbours a polymorphic CAG repeat in the amino‐terminal coding region with yet unproven function. Hypothesizing that KCNN3 genotypes do not influence susceptibility to schizophrenia but modify its phenotype, we explored their contribution to specific schizophrenic symptoms. Using the Göttingen Research Association for Schizophrenia (GRAS) data collection of schizophrenic patients (n = 1074), we performed a phenotype‐based genetic association study (PGAS) of KCNN3. We show that long CAG repeats in the schizophrenic sample are specifically associated with better performance in higher cognitive tasks, comprising the capacity to discriminate, select and execute (p 
ISSN:1757-4676
1757-4684
DOI:10.1002/emmm.201100135