Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases

Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of act...

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Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Liu, Fu-you, Shuguang, Yuan, Xiangqing, Xu, Jun, Li, Jiazhen, Tan, Xuejing, Zhu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apoptosis
Biomarkers
Biomarkers - urine
Biopsy
Blood
Chemokine CCL2 - urine
Chi-Square Distribution
Creatinine
Cytokine TWEAK
Female
Histocytochemistry
Histopathology
Humans
Kidney - chemistry
Kidney - pathology
Kidney diseases
Lupus
Lupus Nephritis - urine
Male
Middle Aged
Tumor Necrosis Factors - urine
Urine
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cited_by cdi_FETCH-LOGICAL-c565t-1b94998a203e622036513f26c2115ecbfa0055b18fdb61849e616aa8bb4bf6833
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creator Liu, Fu-you
Shuguang, Yuan
Xiangqing, Xu
Jun, Li
Jiazhen, Tan
Xuejing, Zhu
description Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825, P
doi_str_mv 10.1155/2012/359647
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This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825, P&lt;0.01), glomerular activity index (r=  0.754, P&lt;0.01), and tubulointerstitial qualitative activity index (r=0.751, P&lt;0.01), while not significant correlated with chronicity Index (P&gt;0.05). The association between urinary TWEAK levels and urinary MCP-1 levels were significant in active LN group (r=0.809, P&lt;0.01) but not significant in non-active LN group (P&gt;0.05). Conclusions. uWEAK levels were correlated with all active indexes of LN, suggesting its potential role as novel biomarker of active lupus nephritis.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2012/359647</identifier><identifier>PMID: 22719208</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adolescent ; Adult ; Apoptosis ; Biomarkers ; Biomarkers - urine ; Biopsy ; Blood ; Chemokine CCL2 - urine ; Chi-Square Distribution ; Creatinine ; Cytokine TWEAK ; Female ; Histocytochemistry ; Histopathology ; Humans ; Kidney - chemistry ; Kidney - pathology ; Kidney diseases ; Lupus ; Lupus Nephritis - urine ; Male ; Middle Aged ; Tumor Necrosis Factors - urine ; Urine</subject><ispartof>BioMed research international, 2012-01, Vol.2012 (2012), p.1-7</ispartof><rights>Copyright © 2012 Zhu Xuejing et al.</rights><rights>Copyright © 2012 Zhu Xuejing et al. Zhu Xuejing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2012 Zhu Xuejing et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-1b94998a203e622036513f26c2115ecbfa0055b18fdb61849e616aa8bb4bf6833</citedby><cites>FETCH-LOGICAL-c565t-1b94998a203e622036513f26c2115ecbfa0055b18fdb61849e616aa8bb4bf6833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375113/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375113/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22719208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Paula, Sergio O.</contributor><creatorcontrib>Liu, Fu-you</creatorcontrib><creatorcontrib>Shuguang, Yuan</creatorcontrib><creatorcontrib>Xiangqing, Xu</creatorcontrib><creatorcontrib>Jun, Li</creatorcontrib><creatorcontrib>Jiazhen, Tan</creatorcontrib><creatorcontrib>Xuejing, Zhu</creatorcontrib><title>Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825, P&lt;0.01), glomerular activity index (r=  0.754, P&lt;0.01), and tubulointerstitial qualitative activity index (r=0.751, P&lt;0.01), while not significant correlated with chronicity Index (P&gt;0.05). The association between urinary TWEAK levels and urinary MCP-1 levels were significant in active LN group (r=0.809, P&lt;0.01) but not significant in non-active LN group (P&gt;0.05). Conclusions. uWEAK levels were correlated with all active indexes of LN, suggesting its potential role as novel biomarker of active lupus nephritis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Chemokine CCL2 - urine</subject><subject>Chi-Square Distribution</subject><subject>Creatinine</subject><subject>Cytokine TWEAK</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Kidney - chemistry</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Lupus</subject><subject>Lupus Nephritis - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Tumor Necrosis Factors - urine</subject><subject>Urine</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqF0c1r2zAYBnAxNvp92nlF0EvpSKtXX5YvhRDabizbLi07Ctl53ahz7FSyU_rfT8Zt2HbpRRLox4NePYR8BHYOoNQFZ8AvhMq1zN6RPQBgk4wreL89S7FL9mN8YAwyo_Mdsst5BjlnZo_c3AXfuPBMb39dTb_ROW6wpi5SR7-78BsDbSs679d9pD9wvQy-85FOy85vfPdMfUOlpjMXMR6SD5WrIx697Afk7vrqdvZlMv9583U2nU9KpVU3gSKXeW4cZwI1T6tWICquS55GwbKoHGNKFWCqRaHByBw1aOdMUcii0kaIA3I55q77YoWLEpsuuNqug1-lKWzrvP33pvFLe99urBCZAhgCTl8CQvvYY-zsyscS69o12PbRAk9PkUpp_jZlHHIDmg2pJ__Rh7YPTfqJQWUqU8qYpD6PqgxtjAGr7buB2aFLO3Rpxy6TPv571K19LS-BsxEsfbNwT_6NtE8jxkSwclsstcokF38AHUSsRg</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Liu, Fu-you</creator><creator>Shuguang, Yuan</creator><creator>Xiangqing, Xu</creator><creator>Jun, Li</creator><creator>Jiazhen, Tan</creator><creator>Xuejing, Zhu</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases</title><author>Liu, Fu-you ; 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De Paula</notes><abstract>Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825, P&lt;0.01), glomerular activity index (r=  0.754, P&lt;0.01), and tubulointerstitial qualitative activity index (r=0.751, P&lt;0.01), while not significant correlated with chronicity Index (P&gt;0.05). The association between urinary TWEAK levels and urinary MCP-1 levels were significant in active LN group (r=0.809, P&lt;0.01) but not significant in non-active LN group (P&gt;0.05). Conclusions. uWEAK levels were correlated with all active indexes of LN, suggesting its potential role as novel biomarker of active lupus nephritis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>22719208</pmid><doi>10.1155/2012/359647</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Apoptosis
Biomarkers
Biomarkers - urine
Biopsy
Blood
Chemokine CCL2 - urine
Chi-Square Distribution
Creatinine
Cytokine TWEAK
Female
Histocytochemistry
Histopathology
Humans
Kidney - chemistry
Kidney - pathology
Kidney diseases
Lupus
Lupus Nephritis - urine
Male
Middle Aged
Tumor Necrosis Factors - urine
Urine
title Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases
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