Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases

Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of act...

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Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Liu, Fu-you, Shuguang, Yuan, Xiangqing, Xu, Jun, Li, Jiazhen, Tan, Xuejing, Zhu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apoptosis
Biomarkers
Biomarkers - urine
Biopsy
Blood
Chemokine CCL2 - urine
Chi-Square Distribution
Creatinine
Cytokine TWEAK
Female
Histocytochemistry
Histopathology
Humans
Kidney - chemistry
Kidney - pathology
Kidney diseases
Lupus
Lupus Nephritis - urine
Male
Middle Aged
Tumor Necrosis Factors - urine
Urine
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Summary:Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index (r=0.825, P
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/359647