Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of virus in host tissues prior to the induction of...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-14
Main Authors: Ng, Wy Ching, Tate, Michelle D., Brooks, Andrew G., Reading, Patrick C.
Format: Article
Language:English
Subjects:
Animals
Biotechnology
Fluid dynamics
Fluid flow
Fluids
Host-Pathogen Interactions
Humans
Immunity, Innate
Influenza
Influenza A virus - immunology
Influenza virus
Lectins
Lectins - immunology
Mutation
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - virology
Pandemics
Proteins
Review
Spreads
Viruses
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Summary:Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of virus in host tissues prior to the induction of the adaptive immune response. Serum and lung fluids contain a range of lectins capable of recognizing and destroying influenza A viruses (IAV). Herein, we review the mechanisms by which soluble endogenous lectins mediate anti-IAV activity, including their role in modulating IAV-induced inflammation and disease and their potential as prophylactic and/or therapeutic treatments during severe IAV-induced disease.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/732191