Associations of salivary cortisol levels with inflammatory markers: The Multi-Ethnic Study of Atherosclerosis

Summary Socioeconomic and psychosocial factors have been found to be associated with systemic inflammation. Although stress is often proposed as a contributor to these associations, no population studies have investigated the links between inflammation and biomarkers of stress. The current study exa...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2012-07, Vol.37 (7), p.1009-1018
Main Authors: DeSantis, A.S, DiezRoux, A.V, Hajat, A, Aiello, A.E, Golden, S.H, Jenny, N.S, Seeman, T.E, Shea, S
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arteriosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Atherosclerosis - epidemiology
Atherosclerosis - ethnology
Atherosclerosis - metabolism
Behavioral psychophysiology
Biological and medical sciences
biomarkers
Biomarkers - blood
Biomarkers - metabolism
Blood and lymphatic vessels
Cardiology. Vascular system
Cortisol
Cytokines
Data processing
Endocrinology & Metabolism
Ethnic Groups - statistics & numerical data
Female
Fundamental and applied biological sciences. Psychology
Hormones and behavior
HPA axis
Humans
Hydrocortisone
Hydrocortisone - analysis
Hydrocortisone - metabolism
Hypothalamic-pituitary-adrenal axis
Inflammation
Inflammation - blood
Inflammation - epidemiology
Inflammation - ethnology
Inflammation - metabolism
Interleukin 10
Interleukin 6
Interleukin-6 - analysis
Interleukin-6 - blood
Interleukin-6 - metabolism
Longitudinal Studies
Male
Medical sciences
Middle Aged
Obesity - blood
Obesity - epidemiology
Obesity - ethnology
Obesity - metabolism
Overweight - blood
Overweight - epidemiology
Overweight - ethnology
Overweight - metabolism
Population studies
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Risk factors
Saliva - chemistry
Saliva - metabolism
Socio-economic aspects
Stress
Tumor necrosis factor- alpha
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Summary:Summary Socioeconomic and psychosocial factors have been found to be associated with systemic inflammation. Although stress is often proposed as a contributor to these associations, no population studies have investigated the links between inflammation and biomarkers of stress. The current study examines associations between daily cortisol profiles and inflammatory markers interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor (TNF-a) in a population-based sample of 869 adults with repeat measures of cortisol over multiple days. Persons with higher levels of IL-6 had a less pronounced cortisol awakening response, a less steep daily decline, and higher cortisol area under the curve for the day with associations persisting after controls for risk factors and other cytokines. Persons with higher levels of TNF-a had lower cortisol levels upon waking, and flatter daily decline, although associations with decline were attenuated when controlling for inflammatory risk factors. Higher levels of IL-10 were associated with marginally flatter daily cortisol decline ( p < .10). This study is the first to identify associations of basal cortisol activity and inflammatory markers in a population based sample. Findings are consistent with the possibility that HPA axis activity may mediate associations between psychosocial stressors and inflammatory processes. Additional prospective data are necessary to clarify the directionality of associations between cortisol and inflammatory markers.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2011.11.009