Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2 H)-furanones, pyrrolones, indolizines, and indolizinones

Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaro...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2008-07, Vol.64 (29), p.7008-7014
Main Authors: Bunnelle, Eric M., Smith, Cameron R., Lee, Sharon K., Singaram, Surendra W., Rhodes, Allison J., Sarpong, Richmond
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2008.02.103