Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health

Al‐Sabbagh M, Alladah A, Lin Y, Kryscio RJ, Thomas MV, Ebersole JL, Miller CS. Bone remodeling‐associated salivary biomarker MIP‐1α distinguishes periodontal disease from health. J Periodont Res 2012; 47: 389–395. © 2011 John Wiley & Sons A/S Background and Objective:  The field of salivary diag...

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Published in:Journal of periodontal research 2012-06, Vol.47 (3), p.389-395
Main Authors: Al-Sabbagh, M., Alladah, A., Lin, Y., Kryscio, R. J., Thomas, M. V., Ebersole, J. L., Miller, C. S.
Format: Article
Language:English
Subjects:
Adult
Area Under Curve
Biological and medical sciences
biomarker
biomarkers
Biomarkers - analysis
Bleeding
Bone (alveolar)
Bone loss
bone remodeling
Bone Remodeling - physiology
Bone remodelling
C-telopeptide pyridinoline cross-links of type I collagen
Case-Control Studies
Chemokine CCL3 - analysis
Chemokines
Chronic Periodontitis - metabolism
Collagen
Collagen Type I - analysis
Cross-linking
Cross-Sectional Studies
Enzymes
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gingival Hemorrhage - metabolism
Humans
Immunosorbents
Inflammation
macrophage inflammatory protein 1
macrophage inflammatory protein-1α
Macrophages
Male
Medical sciences
Middle Aged
Non tumoral diseases
Osteoprotegerin
Osteoprotegerin - analysis
Otorhinolaryngology. Stomatology
Peptides - analysis
Periodontal Attachment Loss - metabolism
periodontal disease
Periodontal diseases
periodontal health
Periodontal Index
Periodontal Pocket - metabolism
Periodontitis
Periodontium - metabolism
pyridinoline
Saliva
Salivary Proteins and Peptides - analysis
Sensitivity and Specificity
Young Adult
β-C-terminal type I collagen telopeptide
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Summary:Al‐Sabbagh M, Alladah A, Lin Y, Kryscio RJ, Thomas MV, Ebersole JL, Miller CS. Bone remodeling‐associated salivary biomarker MIP‐1α distinguishes periodontal disease from health. J Periodont Res 2012; 47: 389–395. © 2011 John Wiley & Sons A/S Background and Objective:  The field of salivary diagnostics lacks an accepted and validated biomarker of alveolar bone remodeling. To address this, we examined levels of salivary biomolecules specifically associated with biological aspects of bone remodeling in subjects with chronic periodontitis in a case–control study. Material and Methods:  Levels of macrophage inflammatory protein‐1α (MIP‐1α), osteoprotegerin, C‐telopeptide pyridinoline cross‐links of type I collagen and β‐C‐terminal type I collagen telopeptide in unstimulated whole saliva of 80 subjects (40 subjects with moderate to severe chronic periodontitis and 40 sex‐ and age‐matched healthy control subjects) were measured using enzyme immunosorbent assays. Saliva was collected before clinical examination, which included probing depth, clinical attachment loss and bleeding on probing. Results:  The mean level of MIP‐1α in subjects with periodontitis was 18‐fold higher than in healthy subjects (p 
ISSN:0022-3484
1600-0765
DOI:10.1111/j.1600-0765.2011.01445.x