Enhanced Brain Correlations during Rest Are Related to Memory for Recent Experiences

Long-term storage of episodic memories is hypothesized to result from the off-line transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent cortical representation to emerge. However, off-line hippocampal-cortical interactions have not been demonstrated to be lin...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Mass.), 2010-01, Vol.65 (2), p.280-290
Main Authors:	Tambini, Arielle, Ketz, Nicholas, Davachi, Lila
Format:	Article
Language:	eng
Subjects:	Adult Behavior Brain Brain - physiology Brain mapping Confidence intervals Female Humans Male Memory - physiology Photic Stimulation - methods Psychomotor Performance - physiology Rest - physiology Rodents Sleep SYSNEURO Time Factors Young Adult
Online Access:	Get full text
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Summary:	Long-term storage of episodic memories is hypothesized to result from the off-line transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent cortical representation to emerge. However, off-line hippocampal-cortical interactions have not been demonstrated to be linked with long-term memory. Here, using functional magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations during rest following an associative encoding task are related to later associative memory performance. Our data show enhanced functional connectivity between the hippocampus and a portion of the lateral occipital complex (LO) during rest following a task with high subsequent memory compared to pretask baseline resting connectivity. This effect is not seen during rest following a task with poor subsequent memory. Furthermore, the magnitude of hippocampal-LO correlations during posttask rest predicts individual differences in later associative memory. These results demonstrate the importance of postexperience resting brain correlations for memory for recent experiences. [Display omitted] ► High subsequent memory tasks preferentially increase functional connectivity at rest ► Resting cortical correlations are modulated by success of prior memory encoding ► Resting hippocampal-cortical correlations are also modulated by prior encoding ► Posttask hippocampal-cortical resting correlations predict later associative memory
ISSN:	0896-6273 1097-4199