Population differences in immune responses to BCG in infancy1

BCG vaccination induces a marked increase in the IFNγ response to M.tb PPD in UK, but not Malawian adolescents. We hypothesized that PPD-induced IFNγ following BCG vaccination would be similar in infants in the two countries. Infants were BCG-vaccinated in the first 3-13 weeks of life. Three months...

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Bibliographic Details
Published in:The Journal of infectious diseases 2009-03, Vol.199 (6), p.795-800
Main Authors: Lalor, Maeve K., Ben-Smith, Anne, Gorak-Stolinska, Patricia, Weir, Rosemary E., Floyd, Sian, Blitz, Rose, Mvula, Hazzie, Newport, Melanie J., Branson, Keith, McGrath, Nuala, Crampin, Amelia C., Fine, Paul E. M., Dockrell, Hazel M.
Format: Article
Language:English
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Summary:BCG vaccination induces a marked increase in the IFNγ response to M.tb PPD in UK, but not Malawian adolescents. We hypothesized that PPD-induced IFNγ following BCG vaccination would be similar in infants in the two countries. Infants were BCG-vaccinated in the first 3-13 weeks of life. Three months post-BCG, 100% (51/51) of UK infants made an IFNγ response to M.tb PPD, compared to 53% of Malawian infants in whom responses varied by season of birth. We conclude that population differences in immune responses following BCG vaccination are observed in infants, as well as in young adults.
ISSN:0022-1899
1537-6613