Regulation of Osteogenesis‐Angiogenesis Coupling by HIFs and VEGF

Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis in bone are only partially elucidated. Genetic manipulations in mice have recently highlighted the critical role of...

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Bibliographic Details
Published in:Journal of bone and mineral research 2009-08, Vol.24 (8), p.1347-1353
Main Authors: Schipani, Ernestina, Maes, Christa, Carmeliet, Geert, Semenza, Gregg L
Format: Article
Language:English
Subjects:
angiogenesis
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
hypoxia inducible factor
Hypoxia-Inducible Factor 1 - physiology
Mice
Neovascularization, Physiologic
osteoblast
Osteogenesis
Skeleton and joints
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - physiology
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis in bone are only partially elucidated. Genetic manipulations in mice have recently highlighted the critical role of the hypoxia‐inducible‐factor/vascular endothelial growth factor pathway in coupling angiogenesis and osteogenesis. In this brief perspective, we review the current understanding of the mechanisms responsible for this coupling. Elucidation of such mechanisms will expand our knowledge of bone development and homeostasis, and it may aid in the design of new therapies for accelerating bone regeneration and repair.
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.090602