Urinary human polyomavirus and papillomavirus infection and bladder cancer risk

The association of transitional cell carcinomas of the bladder (TCB) with Schistosoma haematobium suggested a possible role of infections in the aetiology of TCB. In all, 114 TCB cases and 140 hospital controls from Pordenone Province were enrolled within an Italian multi-centric case-control study....

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Bibliographic Details
Published in:British journal of cancer 2012-01, Vol.106 (1), p.222-226
Main Authors: POLESEL, J, GHEIT, T, TALAMINI, R, SHAHZAD, N, LENARDON, O, SYLLA, B, LA VECCHIA, C, SERRAINO, D, TOMMASINO, M, FRANCESCHI, S
Format: Article
Language:English
Subjects:
Aged
Bacterial diseases
Bacterial diseases of the urinary system
Biological and medical sciences
Bladder cancer
Cancer
Carcinoma, Transitional Cell - complications
DNA
Epidemiology
Female
Hospitals
Human bacterial diseases
Human papillomavirus
Humans
Infection
Infectious diseases
JC virus
Male
Medical sciences
Mucosa
Papillomavirus Infections - complications
Papillomavirus Infections - urine
Polymerase Chain Reaction
Polyomavirus
Polyomavirus Infections - complications
Polyomavirus Infections - urine
Risk Factors
Schistosoma haematobium
Sex
Simian virus 40
Smoking
transitional cell carcinoma
Tumors
Urinary bladder
Urinary Bladder Neoplasms - complications
Urine
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Summary:The association of transitional cell carcinomas of the bladder (TCB) with Schistosoma haematobium suggested a possible role of infections in the aetiology of TCB. In all, 114 TCB cases and 140 hospital controls from Pordenone Province were enrolled within an Italian multi-centric case-control study. Urine samples were screened for DNA from five human polyomaviruses (HPyV) (JCV, BKV, MCV, WUV, and KIV); SV40; and 22 mucosal human papillomaviruses (HPV) using highly sensitive PCR assays. Odds ratios (ORs) and corresponding confidence intervals (CIs) were computed for risk of TCB by HPyV- or HPV-positivity using unconditional logistic regression. Human polyomavirus prevalence was similar in TCB cases (71.7%) and controls (77.7%) (OR for TCB=0.85; 95% CI: 0.45-1.61). JCV was the most frequently detected HPyV type. No individual HPyV showed a significant association. Among cases, HPyV-positivity was not associated with tumour characteristics, but it was significantly lower in women than men and among current and former smokers than never smokers. Human papillomavirus was detected in seven cases and five controls (OR=1.52; 95% CI: 0.42-5.45). The present small study does not support an involvement of HPyV or HPV infection in TCB aetiology in immunocompetent individuals. Differences in HPyV-positivity by sex and smoking may derive from differences in either acquisition or persistence of the infection.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2011.519