Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease

Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link betw...

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Bibliographic Details
Published in:Current cardiovascular risk reports 2012-02, Vol.6 (1), p.80-90
Main Authors: Houben, A. J., Eringa, E. C., Jonk, A. M., Serne, E. H., Smulders, Y. M., Stehouwer, C. D.
Format: Article
Language:English
Subjects:
Blood pressure
Blood vessels
Body fat
Cardiology
Cardiovascular disease
Diabetes
Diabetes and Insulin Resistance (JB Meigs and M Rutter
Diabetes and Insulin Resistance (JB Meigs and M Rutter, Section Editors)
Endothelium
Fatty acids
Glucose
Hormones
Hypertension
Insulin resistance
Kinases
Medicine
Medicine & Public Health
Metabolism
Musculoskeletal system
Nitric oxide
Obesity
Pathogenesis
Section Editors
Stem cells
Veins & arteries
Weight control
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Summary:Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link between insulin resistance and hypertension in obesity. Many studies have shown that adipose tissue-derived substances (adipokines) interact with (micro)vascular function and influence insulin sensitivity. In the past, research focused on adipokines from perivascular adipose tissue (PVAT). In this review, we focus on the interactions between adipokines, predominantly from PVAT, and microvascular function in relation to the development of insulin resistance, diabetes, and cardiovascular disease.
ISSN:1932-9520
1932-9563
DOI:10.1007/s12170-011-0214-0