The ins and outs of leukocyte integrin signaling

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and activation in the immune system. These receptors signal bidirectionally through the plasma membrane in pathways referred to as inside-out and outside-in signaling. Each of these pathways is mediated by conformat...

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Bibliographic Details
Published in:Annual review of immunology 2009-01, Vol.27 (1), p.339-362
Main Authors: Abram, Clare L, Lowell, Clifford A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cell Movement
Cytoskeleton - immunology
Cytoskeleton - metabolism
Endothelial Cells - immunology
Endothelial Cells - metabolism
Extracellular Matrix - immunology
Extracellular Matrix - metabolism
Humans
Integrins - chemistry
Integrins - genetics
Integrins - immunology
Integrins - metabolism
Leukocytes - immunology
Leukocytes - metabolism
Mice
Molecular Sequence Data
Protein Kinases - immunology
Protein Kinases - metabolism
rap GTP-Binding Proteins - immunology
rap GTP-Binding Proteins - metabolism
Signal Transduction
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Summary:Integrins are the principal cell adhesion receptors that mediate leukocyte migration and activation in the immune system. These receptors signal bidirectionally through the plasma membrane in pathways referred to as inside-out and outside-in signaling. Each of these pathways is mediated by conformational changes in the integrin structure. Such changes allow high-affinity binding of the receptor with counter-adhesion molecules on the vascular endothelium or extracellular matrix and lead to association of the cytoplasmic tails of the integrins with intracellular signaling molecules. Leukocyte functional responses resulting from outside-in signaling include migration, proliferation, cytokine secretion, and degranulation. Here, we review the key signaling events that occur in the inside-out versus outside-in pathways, highlighting recent advances in our understanding of how integrins are activated by a variety of stimuli and how they mediate a diverse array of cellular responses.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.021908.132554