Response to Pneumococcal (PNCRM7) and Haemophilus influenza conjugate vaccines (HIB) in pediatric and adult recipients of an allogeneic hematopoietic cell transplantation (alloHCT)

Young children and allogeneic HCT recipients respond poorly to polysaccharide antigens rendering them susceptible to severe infections due to encapsulated bacteria. This study evaluated the responses of 127 HCT patients, median age: 23.0 years, vaccinated with PnCRM7 and HIB, two conjugate vaccines...

Full description

Saved in:
Bibliographic Details
Published in:Biology of blood and marrow transplantation 2008-09, Vol.14 (9), p.1022-1030
Main Authors: Pao, Mary, Papadopoulos, Esperanza B, Chou, Joanne, Glenn, Heller, Castro-Malaspina, Hugo, Jakubowski, Ann A, Kernan, Nancy A, Perales, Miguel A, Prockop, Susan, Scaradavou, Andromachi, vanDenBrink, Marcel R, Young, James W, O'Reilly, Richard J, Small, Trudy N
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Young children and allogeneic HCT recipients respond poorly to polysaccharide antigens rendering them susceptible to severe infections due to encapsulated bacteria. This study evaluated the responses of 127 HCT patients, median age: 23.0 years, vaccinated with PnCRM7 and HIB, two conjugate vaccines highly immunogenic in healthy children. Median time to vaccination was 1.1 years after HCT. Sixty-two percent of patients responded to PNCRM7 (45/51 children, 34/76 adults, p500 mg/dl, PHA within 60% lower limit of normal (11/19 vs 0/8, p
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2008.06.012