Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

In mammals, the inheritance of mitochondrion and its DNA （mtDNA） is strictly maternal, despite the fact that a sperm can inject up to 100 functional mitochondria into the oocyte during fertilization. The mechanisms respon- sible for the elimination of the paternal mitochondria remain largely unknown...

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Bibliographic Details
Published in:Cell research 2011-12, Vol.21 (12), p.1662-1669
Main Authors: Zhou, Qinghua, Li, Haimin, Xue, Ding
Format: Article
Language:English
Subjects:
Animals
Autophagy
Caenorhabditis elegans - embryology
Caenorhabditis elegans Proteins - antagonists & inhibitors
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
DNA, Mitochondrial - metabolism
Embryo, Nonmammalian - metabolism
Lysosomes - metabolism
Male
Mitochondria - metabolism
mtDNA
Original
Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
RNA Interference
Time Factors
Ubiquitin - metabolism
受精过程
哺乳动物
溶酶体
父亲
线粒体
线虫
降解途径
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Summary:In mammals, the inheritance of mitochondrion and its DNA （mtDNA） is strictly maternal, despite the fact that a sperm can inject up to 100 functional mitochondria into the oocyte during fertilization. The mechanisms respon- sible for the elimination of the paternal mitochondria remain largely unknown. We report here that this paternal mitochondrial elimination process is conserved in Caenorhabditis elegans, and that the lysosomal pathway actively participates in this process. Molecular and cell biological analyses indicate that in wild-type animals paternal mito- chondria and mtDNA are destroyed within two hours after fertilization. In animals with compromised lysosomes, pa- ternal mitochondria persist until late embryonic stages. Therefore, the lysosomal pathway plays an important role in degrading paternal mitochondria introduced into the oocyte during fertilization. Our study indicates that C. elegans is an excellent animal model for understanding and dissecting this conserved biological process critical for animal de- velopment and reproduction.
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2011.182