A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene

Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors....

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Bibliographic Details
Published in:European journal of human genetics : EJHG 2012-01, Vol.20 (1), p.84-90
Main Authors: GREGERSEN, Noomi, DAHL, Hans A, KRISTENSEN, Ann S, KRUSE, Torben A, BØRGLUM, Anders D, MORS, Ole, BUTTENSCHØN, Henriette N, NYEGAARD, Mette, HEDEMAND, Anne, ALS, Thomas D, WANG, August G, JOENSEN, Sofus, WOLDBYE, David Pd, KOEFOED, Pernille
Format: Article
Language:English
Subjects:
Acid Sensing Ion Channels
Adult and adolescent clinical studies
Alleles
Amiloride
Anxiety
Anxiety disorders. Neuroses
Autism
Bioinformatics
Biological and medical sciences
Case-Control Studies
Chromosome 17
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 17 - genetics
Degenerin Sodium Channels
Denmark - epidemiology
Denmark - ethnology
Environmental factors
Epithelial Sodium Channels - genetics
Ethnic Groups - genetics
Fundamental and applied biological sciences. Psychology
Gene mapping
General aspects. Genetic counseling
Genes
Genetic factors
Genetic markers
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genomes
Genomics
Genotype
Haplotypes
Humans
Islands
Kinases
Life Sciences
Medical genetics
Medical sciences
Mental disorders
Microsatellite Repeats
Microsatellites
Molecular and cellular biology
Nerve Tissue Proteins - genetics
Panic attacks
Panic disorder
Panic Disorder - diagnosis
Panic Disorder - epidemiology
Panic Disorder - genetics
Polymorphism, Single Nucleotide
Population
Population genetics
Population Groups - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizophrenia
Single-nucleotide polymorphism
Studies
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Summary:Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.
ISSN:1018-4813
1476-5438
DOI:10.1038/ejhg.2011.148