Deciphering the role of nuclear factor-κB in cellular senescence

Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear fa...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2011-10, Vol.3 (10), p.913-919
Main Authors: Vaughan, Simon, Jat, Parmjit S
Format: Article
Language:English
Subjects:
Cell Cycle - physiology
Cellular Senescence - physiology
Humans
NF-kappa B - metabolism
Poly(ADP-ribose) Polymerases - metabolism
Signal Transduction - physiology
Telomere - metabolism
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Summary:Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear factor-κB in cellular senescence is controversial, as it has been associated with both proliferation and tumour progression, and also with growth arrest and ageing. This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100390