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Mixed leukocyte reactivity and leukemia: study of identical siblings
This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stim...
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Published in: | The Journal of clinical investigation 1970-12, Vol.49 (12), p.2271-2275 |
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container_title | The Journal of clinical investigation |
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creator | Rudolph, R H Mickelson, E Thomas, E D |
description | This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stimulate the cells of the normal twin, nor did cells from the normal twin stimulate cells from the leukemic patient. Possible explanations for the failure to detect a leukemia-associated antigen in these studies are discussed. |
doi_str_mv | 10.1172/JCI106446 |
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Possible explanations for the failure to detect a leukemia-associated antigen in these studies are discussed.</description><subject>Antigens</subject><subject>Culture Techniques</subject><subject>Diseases in Twins - immunology</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - immunology</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - metabolism</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - immunology</subject><subject>Thymidine - metabolism</subject><subject>Transplantation Immunology</subject><subject>Tritium</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><recordid>eNpVkMtOwzAQRS0EKuWx4AOQskJiEfDbDhILVF5FRWy6txxnXAxpUuKkIn9PUKsKViPNnDtz5yJ0RvAVIYpev0ymBEvO5R4aEyF0qinT-2iMMSVpppg-REcxfmBMOBd8hEaCDk3Mx-j-NXxDkZTQfdaubyFpwLo2rEPbJ7baDGAZ7E0S267ok9onoYCqDc6WSQx5GapFPEEH3pYRTrf1GM0fH-aT53T29jSd3M1Sx2TWppnMnJKWWlAavATHlSVaCDX84GShPcWM5j4XXhacFMLnmc6ZYFYK7Dllx-h2s3bV5Uso3GCjsaVZNWFpm97UNpj_kyq8m0W9NoxSRfWgv9jqm_qrg9iaZYgOytJWUHfRaK64wIQM4OUGdE0dYwN-d4Ng8xu42QU-sOd_Te3IbcLsBwEdfE8</recordid><startdate>19701201</startdate><enddate>19701201</enddate><creator>Rudolph, R H</creator><creator>Mickelson, E</creator><creator>Thomas, E D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19701201</creationdate><title>Mixed leukocyte reactivity and leukemia: study of identical siblings</title><author>Rudolph, R H ; Mickelson, E ; Thomas, E D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-969c76a2ae78ef6ec47a18557117c6d8f2032bfb5f6d41d5fb98b353a650f423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Antigens</topic><topic>Culture Techniques</topic><topic>Diseases in Twins - immunology</topic><topic>Humans</topic><topic>Leukemia, Lymphoid - immunology</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - metabolism</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - immunology</topic><topic>Thymidine - metabolism</topic><topic>Transplantation Immunology</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rudolph, R H</creatorcontrib><creatorcontrib>Mickelson, E</creatorcontrib><creatorcontrib>Thomas, E D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rudolph, R H</au><au>Mickelson, E</au><au>Thomas, E D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed leukocyte reactivity and leukemia: study of identical siblings</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1970-12-01</date><risdate>1970</risdate><volume>49</volume><issue>12</issue><spage>2271</spage><epage>2275</epage><pages>2271-2275</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. 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subjects | Antigens Culture Techniques Diseases in Twins - immunology Humans Leukemia, Lymphoid - immunology Leukemia, Myeloid, Acute - immunology Leukocytes - immunology Leukocytes - metabolism Lymphocyte Activation Lymphocytes - immunology Thymidine - metabolism Transplantation Immunology Tritium |
title | Mixed leukocyte reactivity and leukemia: study of identical siblings |
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