Mixed leukocyte reactivity and leukemia: study of identical siblings

This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stim...

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Bibliographic Details
Published in:The Journal of clinical investigation 1970-12, Vol.49 (12), p.2271-2275
Main Authors: Rudolph, R H, Mickelson, E, Thomas, E D
Format: Article
Language:English
Subjects:
Antigens
Culture Techniques
Diseases in Twins - immunology
Humans
Leukemia, Lymphoid - immunology
Leukemia, Myeloid, Acute - immunology
Leukocytes - immunology
Leukocytes - metabolism
Lymphocyte Activation
Lymphocytes - immunology
Thymidine - metabolism
Transplantation Immunology
Tritium
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Summary:This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stimulate the cells of the normal twin, nor did cells from the normal twin stimulate cells from the leukemic patient. Possible explanations for the failure to detect a leukemia-associated antigen in these studies are discussed.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI106446