Dynamic arterial elastance to predict arterial pressure response to volume loading in preload-dependent patients

Hemodynamic resuscitation should be aimed at achieving not only adequate cardiac output but also sufficient mean arterial pressure (MAP) to guarantee adequate tissue perfusion pressure. Since the arterial pressure response to volume expansion (VE) depends on arterial tone, knowing whether a patient...

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Bibliographic Details
Published in:Critical care (London, England) England), 2011-01, Vol.15 (1), p.R15-R15
Main Authors: Monge García, Manuel Ignacio, Gil Cano, Anselmo, Gracia Romero, Manuel
Format: Article
Language:English
Subjects:
Adult
Artificial respiration
Blood circulation disorders
Blood Pressure
Care and treatment
Female
Fluid Therapy
Health aspects
Hemodynamics
Humans
Male
Measurement
Middle Aged
Monitoring, Physiologic - methods
Multivariate Analysis
Patient outcomes
Prospective Studies
Respiration, Artificial
ROC Curve
Sensitivity and Specificity
Shock - physiopathology
Shock - therapy
Stroke Volume
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Summary:Hemodynamic resuscitation should be aimed at achieving not only adequate cardiac output but also sufficient mean arterial pressure (MAP) to guarantee adequate tissue perfusion pressure. Since the arterial pressure response to volume expansion (VE) depends on arterial tone, knowing whether a patient is preload-dependent provides only a partial solution to the problem. The objective of this study was to assess the ability of a functional evaluation of arterial tone by dynamic arterial elastance (Ea(dyn)), defined as the pulse pressure variation (PPV) to stroke volume variation (SVV) ratio, to predict the hemodynamic response in MAP to fluid administration in hypotensive, preload-dependent patients with acute circulatory failure. We performed a prospective clinical study in an adult medical/surgical intensive care unit in a tertiary care teaching hospital, including 25 patients with controlled mechanical ventilation who were monitored with the Vigileo(®) monitor, for whom the decision to give fluids was made because of the presence of acute circulatory failure, including arterial hypotension (MAP ≤65 mmHg or systolic arterial pressure 0.89 predicted a MAP increase after fluid administration with a sensitivity of 93.75% (95% CI, 69.8%-99.8%) and a specificity of 100% (95% CI, 66.4%-100%). Functional assessment of arterial tone by Ea(dyn), measured as the PVV to SVV ratio, predicted arterial pressure response after volume loading in hypotensive, preload-dependent patients under controlled mechanical ventilation.
ISSN:1364-8535
1466-609X
DOI:10.1186/cc9420