Mitochondrial complex I and cell death: a semi-automatic shotgun model

Mitochondrial dysfunction often leads to cell death and disease. We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase or complex I, and its structural organization thanks to the recent advances in the X-ray structure of it...

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Bibliographic Details
Published in:Cell death & disease 2011-10, Vol.2 (10), p.e222-e222
Main Authors: Gonzalez-Halphen, D, Ghelli, A, Iommarini, L, Carelli, V, Esposti, M D
Format: Article
Language:English
Subjects:
Cell death
Cell Death - physiology
Electron Transport Complex I - genetics
Electron Transport Complex I - metabolism
Humans
Mitochondrial Diseases - genetics
Mitochondrial Diseases - metabolism
Mitochondrial Diseases - pathology
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Summary:Mitochondrial dysfunction often leads to cell death and disease. We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase or complex I, and its structural organization thanks to the recent advances in the X-ray structure of its bacterial homologs. The new structural information on bacterial complex I provide essential clues to finally understand how complex I may work. However, the same information remains difficult to interpret for many scientists working on mitochondrial complex I from different angles, especially in the field of cell death. Here, we present a novel way of interpreting the bacterial structural information in accessible terms. On the basis of the analogy to semi-automatic shotguns, we propose a novel functional model that incorporates recent structural information with previous evidence derived from studies on mitochondrial diseases, as well as functional bioenergetics.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2011.107