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Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performa...
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| Published in: | NeuroImage (Orlando, Fla.) Fla.), 2012-01, Vol.59 (1), p.738-744 |
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| creator | Foland-Ross, Lara C. Bookheimer, Susan Y. Lieberman, Matthew D. Sugar, Catherine A. Townsend, Jennifer D. Fischer, Jeffrey Torrisi, Salvatore Penfold, Conor Madsen, Sarah K. Thompson, Paul M. Altshuler, Lori L. |
| description | Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
► We compare activation between euthymic bipolar and control subjects using fMRI. ► Amygdala reactivity did not differ between euthymic bipolar and control subjects. ► PFC activation was lower in euthymic bipolar compared to control subjects. ► Dysfunction of the PFC may represent a trait marker of bipolar illness. ► Dysfunction of the amygdala may represent a mood-state marker of bipolar illness. |
| doi_str_mv | 10.1016/j.neuroimage.2011.07.054 |
| format | article |
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► We compare activation between euthymic bipolar and control subjects using fMRI. ► Amygdala reactivity did not differ between euthymic bipolar and control subjects. ► PFC activation was lower in euthymic bipolar compared to control subjects. ► Dysfunction of the PFC may represent a trait marker of bipolar illness. ► Dysfunction of the amygdala may represent a mood-state marker of bipolar illness.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2011.07.054</identifier><identifier>PMID: 21854858</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Affective disorders ; Amygdala ; Amygdala - physiopathology ; Bipolar disorder ; Bipolar Disorder - physiopathology ; Brain Mapping ; Charitable foundations ; Demography ; Emotion ; Female ; fMRI ; Gender ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Prefrontal cortex ; Prefrontal Cortex - physiopathology ; Studies</subject><ispartof>NeuroImage (Orlando, Fla.), 2012-01, Vol.59 (1), p.738-744</ispartof><rights>2011</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Jan 2, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-3a70d46e39a07ab6736421a872044f52d6c135839a8ecf0e442337ece6b5e33c3</citedby><cites>FETCH-LOGICAL-c538t-3a70d46e39a07ab6736421a872044f52d6c135839a8ecf0e442337ece6b5e33c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21854858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foland-Ross, Lara C.</creatorcontrib><creatorcontrib>Bookheimer, Susan Y.</creatorcontrib><creatorcontrib>Lieberman, Matthew D.</creatorcontrib><creatorcontrib>Sugar, Catherine A.</creatorcontrib><creatorcontrib>Townsend, Jennifer D.</creatorcontrib><creatorcontrib>Fischer, Jeffrey</creatorcontrib><creatorcontrib>Torrisi, Salvatore</creatorcontrib><creatorcontrib>Penfold, Conor</creatorcontrib><creatorcontrib>Madsen, Sarah K.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Altshuler, Lori L.</creatorcontrib><title>Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
► We compare activation between euthymic bipolar and control subjects using fMRI. ► Amygdala reactivity did not differ between euthymic bipolar and control subjects. ► PFC activation was lower in euthymic bipolar compared to control subjects. ► Dysfunction of the PFC may represent a trait marker of bipolar illness. ► Dysfunction of the amygdala may represent a mood-state marker of bipolar illness.</description><subject>Adult</subject><subject>Affective disorders</subject><subject>Amygdala</subject><subject>Amygdala - physiopathology</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain Mapping</subject><subject>Charitable foundations</subject><subject>Demography</subject><subject>Emotion</subject><subject>Female</subject><subject>fMRI</subject><subject>Gender</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foland-Ross, Lara C.</au><au>Bookheimer, Susan Y.</au><au>Lieberman, Matthew D.</au><au>Sugar, Catherine A.</au><au>Townsend, Jennifer D.</au><au>Fischer, Jeffrey</au><au>Torrisi, Salvatore</au><au>Penfold, Conor</au><au>Madsen, Sarah K.</au><au>Thompson, Paul M.</au><au>Altshuler, Lori L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2012-01-02</date><risdate>2012</risdate><volume>59</volume><issue>1</issue><spage>738</spage><epage>744</epage><pages>738-744</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
► We compare activation between euthymic bipolar and control subjects using fMRI. ► Amygdala reactivity did not differ between euthymic bipolar and control subjects. ► PFC activation was lower in euthymic bipolar compared to control subjects. ► Dysfunction of the PFC may represent a trait marker of bipolar illness. ► Dysfunction of the amygdala may represent a mood-state marker of bipolar illness.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21854858</pmid><doi>10.1016/j.neuroimage.2011.07.054</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Affective disorders Amygdala Amygdala - physiopathology Bipolar disorder Bipolar Disorder - physiopathology Brain Mapping Charitable foundations Demography Emotion Female fMRI Gender Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Medical imaging Prefrontal cortex Prefrontal Cortex - physiopathology Studies |
| title | Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia |
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