Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia

Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performa...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2012-01, Vol.59 (1), p.738-744
Main Authors: Foland-Ross, Lara C., Bookheimer, Susan Y., Lieberman, Matthew D., Sugar, Catherine A., Townsend, Jennifer D., Fischer, Jeffrey, Torrisi, Salvatore, Penfold, Conor, Madsen, Sarah K., Thompson, Paul M., Altshuler, Lori L.
Format: Article
Language:English
Subjects:
Adult
Affective disorders
Amygdala
Amygdala - physiopathology
Bipolar disorder
Bipolar Disorder - physiopathology
Brain Mapping
Charitable foundations
Demography
Emotion
Female
fMRI
Gender
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical imaging
Prefrontal cortex
Prefrontal Cortex - physiopathology
Studies
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Summary:Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest. ► We compare activation between euthymic bipolar and control subjects using fMRI. ► Amygdala reactivity did not differ between euthymic bipolar and control subjects. ► PFC activation was lower in euthymic bipolar compared to control subjects. ► Dysfunction of the PFC may represent a trait marker of bipolar illness. ► Dysfunction of the amygdala may represent a mood-state marker of bipolar illness.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2011.07.054