Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata

Aims Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance of FAP in thin-cap human fibroatheromata rema...

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Bibliographic Details

Published in:	European heart journal 2011-11, Vol.32 (21), p.2713-2722
Main Authors:	Brokopp, Chad E, Schoenauer, Roman, Richards, Peter, Bauer, Stefan, Lohmann, Christine, Emmert, Maximilian Y, Weber, Benedikt, Winnik, Stephan, Aikawa, Elena, Graves, Kirk, Genoni, Michele, Vogt, Peter, Lüscher, Thomas F, Renner, Christoph, Hoerstrup, Simon P, Matter, Christian M
Format:	Article
Language:	eng
Subjects:	Adult Aged Analysis of Variance Aortic Diseases - metabolism Atherosclerosis (general aspects, experimental research) Basic Science Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Collagen Type I - metabolism Collagenases Coronary Artery Disease - metabolism Endothelial Cells - metabolism Gelatinases - antagonists & inhibitors Gelatinases - metabolism Humans Matrix Metalloproteinase Inhibitors Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Middle Aged Muscle, Smooth, Vascular - metabolism Plaque, Atherosclerotic - metabolism Serine Endopeptidases - metabolism Tumor Necrosis Factor-alpha - pharmacology
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