iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation

Dear editor, Due to its ethical acceptability and technical feasibil ity, production of induced pluripotent stem （iPS） cells from differentiated somatic cells by exogenous expression of several key transcription factors has given great promise to regenerative medicine and drug discovery . The most c...

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Bibliographic Details
Published in:Cell research 2011-03, Vol.21 (3), p.550-553
Main Authors: Li, Wei, Zhao, Xiao-Yang, Wan, Hai-Feng, Zhang, Ying, Liu, Lei, Lv, Zhuo, Wang, Xiu-Jie, Wang, Liu, Zhou, Qi
Format: Article
Language:English
Subjects:
Animals
Cellular Reprogramming
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - metabolism
iPS
Letter to the Editor
Mice
MicroRNAs - metabolism
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Tetraploidy
Transcription Factors - metabolism
体细胞
四倍体
转录因子
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Summary:Dear editor, Due to its ethical acceptability and technical feasibil ity, production of induced pluripotent stem （iPS） cells from differentiated somatic cells by exogenous expression of several key transcription factors has given great promise to regenerative medicine and drug discovery . The most commonly used transcription factors in iPS cell induction are Oct4, Sox2, Klf4 and c-Myc .
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2011.25