Comparison of Biomarkers and Parent Report of Tobacco Exposure to Predict Wheeze

Objective To identify the optimal measure of active and passive prenatal tobacco exposure to predict wheeze in early life. Study design We conducted a birth cohort study of 398 mother-infant dyads enrolled during the second trimester of pregnancy and followed through age 2 years. We measured tobacco...

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Bibliographic Details
Published in:The Journal of pediatrics 2011-11, Vol.159 (5), p.776-782
Main Authors: Spanier, Adam J., MD, PhD, MPH, Kahn, Robert S., MD, MPH, Xu, Yingying, MS, Hornung, Richard, DrPH, Lanphear, Bruce P., MD, MPH
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - analysis
Child, Preschool
Chronic obstructive pulmonary disease, asthma
Cohort Studies
Cotinine - analysis
Female
Follow-Up Studies
General aspects
Humans
Infant
Infant, Newborn
Male
Meconium - chemistry
Medical sciences
Multivariate Analysis
Parents
Pediatrics
Pneumology
Pregnancy
Prenatal Exposure Delayed Effects
Respiratory Sounds - etiology
Self Report
Smoking - adverse effects
Smoking - blood
Tobacco Smoke Pollution - adverse effects
Tobacco Smoke Pollution - analysis
Tobacco, tobacco smoking
Toxicology
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Summary:Objective To identify the optimal measure of active and passive prenatal tobacco exposure to predict wheeze in early life. Study design We conducted a birth cohort study of 398 mother-infant dyads enrolled during the second trimester of pregnancy and followed through age 2 years. We measured tobacco exposure with maternal report, serum cotinine level, and meconium cotinine level. We assessed wheeze with parent report every 6 months. We used a repeated measures logistic regression model. Results Of 367 children with respiratory data, 26% percent had parent reported active or passive prenatal maternal tobacco exposure, but cotinine was detected in 61% of mothers during pregnancy. Compared with children of mothers in the fifth percentile of tobacco exposure, children of mothers in the 95th percentile had increased odds of wheeze when exposure was measured with maternal serum cotinine level (adjusted OR, 2.6; 95% CI, 1.3-5.2; P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2011.04.025