Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicat...

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Bibliographic Details
Published in:Genes & development 2000-11, Vol.14 (21), p.2689-2694
Main Authors: Oldham, S, Montagne, J, Radimerski, T, Thomas, G, Hafen, E
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Carrier Proteins
Cell Cycle Proteins
Drosophila
Drosophila melanogaster - enzymology
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - physiology
Drosophila Proteins
Energy Metabolism - drug effects
Energy Metabolism - genetics
Fungal Proteins - physiology
Genes, Lethal
Insect Proteins - analysis
Insect Proteins - genetics
Insect Proteins - physiology
insulin
Insulin - physiology
Intracellular Signaling Peptides and Proteins
Larva
Peptide Initiation Factors
Phosphatidylinositol 3-Kinases - physiology
Phosphoproteins - physiology
Phosphotransferases (Alcohol Group Acceptor) - analysis
Phosphotransferases (Alcohol Group Acceptor) - genetics
Phosphotransferases (Alcohol Group Acceptor) - physiology
Protein Kinases
rapamycin
Recombinant Fusion Proteins - metabolism
Research Communication
Ribosomal Protein S6 Kinases - physiology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - physiology
Saccharomyces cerevisiae Proteins
Signal Transduction
Sirolimus - pharmacology
Species Specificity
TOR Serine-Threonine Kinases
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Summary:The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicate that dTOR impinges on the insulin signaling pathway by autonomously affecting growth through modulating the activity of dS6K. However, in contrast to other components in the insulin signaling pathway, partial loss of dTOR function preferentially reduces growth of the endoreplicating tissues. These results are consistent with dTOR residing on a parallel amino acid sensing pathway.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.845700