Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPAR delta

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain...

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Bibliographic Details
Published in:Genes & development 1999-06, Vol.13 (12), p.1561-1574
Main Authors: Lim, H, Gupta, R A, Ma, W-G, Paria, B C, Moller, DE, Morrow, J D, DuBois, R N, Trzaskos, J M, Dey, S K
Format: Article
Language:English
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Research Paper
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Summary:We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI sub(2)) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI sub(2) are mediated by its activation of the nuclear hormone receptor PPAR delta , demonstrating the first reported biologic function of this receptor signaling pathway.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.13.12.1561