Schistosoma hematobium-associated glomerulopathy

Schistosomiasis is the second most devastating tropical parasitic disease worldwide and is responsible for many urological complications. However, glomerular injury is a rare complication mainly described with Schistosoma mansoni. We report a case of membranoproliferative glomerulonephritis (MPGN) a...

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Bibliographic Details
Published in:Indian journal of nephrology 2011-07, Vol.21 (3), p.201-203
Main Authors: Seck, S M, Sarr, M L, Dial, M C, Ka, E F
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
Disease
Drug therapy
Health aspects
Hypertension
Kidney diseases
Medical treatment
Praziquantel
Schistosomiasis
Tropical diseases
Urogenital system
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Summary:Schistosomiasis is the second most devastating tropical parasitic disease worldwide and is responsible for many urological complications. However, glomerular injury is a rare complication mainly described with Schistosoma mansoni. We report a case of membranoproliferative glomerulonephritis (MPGN) associated with Schistosoma hematobium infection in a young Senegalese boy living in a rural area. Clinical presentation was with steroid-resistant with nephrotic syndrome. Renal biopsy showed type 1 MPGN with the presence of S. hematobium eggs surrounded by a gigantocellular granuloma. Despite therapy with antihelminthic and immunosuppressive drugs, evolution was characterized by progression to end-stage renal disease over 1 year. More efforts should be made on the prevention and early detection of schistosomiasis among at-risk populations.
ISSN:0971-4065
1998-3662
DOI:10.4103/0971-4065.78076