Apolipoprotein C-III and the Metabolic Basis for Hypertriglyceridemia and the Dense Low-Density Lipoprotein Phenotype

Here, we aim to identify defects of apolipoprotein (apo) B lipoprotein metabolism that characterize hypertriglyceridemia, focusing on apoC-III and apoE. We studied the transport of plasma apoB within 21 distinct subfractions as separated by anti-apoC-III and anti-apoE immunoaffinity chromatography a...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2010-04, Vol.121 (15), p.1722-1734
Main Authors: CHUNYU ZHENG, KHOO, Christina, FURTADO, Jeremy, SACKS, Frank M
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein C-III - metabolism
Apolipoproteins B - metabolism
Apolipoproteins E - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Cardiology. Vascular system
Cholesterol, VLDL - metabolism
Chromatography, Affinity
Dietary Carbohydrates - administration & dosage
Dietary Fats - administration & dosage
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Humans
Hypertriglyceridemia - metabolism
Leucine - pharmacokinetics
Lipoproteins, LDL - biosynthesis
Lipoproteins, LDL - metabolism
Liver - metabolism
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Phenotype
Phenylalanine - pharmacokinetics
Triglycerides - metabolism
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Summary:Here, we aim to identify defects of apolipoprotein (apo) B lipoprotein metabolism that characterize hypertriglyceridemia, focusing on apoC-III and apoE. We studied the transport of plasma apoB within 21 distinct subfractions as separated by anti-apoC-III and anti-apoE immunoaffinity chromatography and ultracentrifugation in 9 patients with moderate hypertriglyceridemia and 12 normotriglyceridemic control subjects. Hypertriglyceridemia was characterized by a 3-fold higher liver secretion of very low-density lipoprotein (VLDL) that had apoC-III but not apoE and a 50% lower secretion of VLDL with both apoC-III and apoE (both P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.109.875807