Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We found that a range of chemoattractants activating G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) an...

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Bibliographic Details
Published in:Cancer cell 2011-06, Vol.19 (6), p.715-727
Main Authors: Schmid, Michael C., Avraamides, Christie J., Dippold, Holly C., Franco, Irene, Foubert, Philippe, Ellies, Lesley G., Acevedo, Lissette M., Manglicmot, Joan R.E., Song, Xiaodan, Wrasidlo, Wolfgang, Blair, Sara L., Ginsberg, Mark H., Cheresh, David A., Hirsch, Emilio, Field, Seth J., Varner, Judith A.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Cell Movement
Class Ib Phosphatidylinositol 3-Kinase - physiology
Disease Progression
Humans
Inflammation - etiology
Integrin alpha4beta1 - physiology
Mice
Mice, Inbred C57BL
Neoplasm Metastasis
Neoplasms - pathology
Neoplasms - prevention & control
ras Proteins - physiology
Receptor Protein-Tyrosine Kinases - physiology
Receptors, Interleukin-1 - physiology
Toll-Like Receptors - physiology
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Summary:Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We found that a range of chemoattractants activating G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and Toll-like/IL-1 receptors (TLR/IL1Rs) unexpectedly initiate tumor inflammation by activating the PI3-kinase isoform p110γ in Gr1+CD11b+ myeloid cells. Whereas GPCRs activate p110γ in a Ras/p101-dependent manner, RTKs and TLR/IL1Rs directly activate p110γ in a Ras/p87-dependent manner. Once activated, p110γ promotes inside-out activation of a single integrin, α4β1, causing myeloid cell invasion into tumors. Pharmacological or genetic blockade of p110γ suppressed inflammation, growth, and metastasis of implanted and spontaneous tumors, revealing an important therapeutic target in oncology. [Display omitted] ► Tumor inflammation depends on myeloid cell p110γ and integrin α4β1 ► RTKs, TLR/ILRs, and GPCRs directly activate p110γ to promote tumor inflammation ► RTKs and TLR/ILRs activate p110γ via p87 and Ras independently of GPCRs ► Inhibitors of p110γ block tumor inflammation, growth, and progression
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2011.04.016