Protein S-Nitrosylation and Cardioprotection

Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein mod...

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Bibliographic Details
Published in:	Circulation research 2010-02, Vol.106 (2), p.285-296
Main Authors:	Sun, Junhui, Murphy, Elizabeth
Format:	Article
Language:	eng
Subjects:	Animals Biological and medical sciences Calcium - metabolism Fundamental and applied biological sciences. Psychology Humans Models, Biological Myocardium - metabolism Nitric Oxide - metabolism Oxidation-Reduction Protein Processing, Post-Translational S-Nitrosothiols - metabolism Sulfhydryl Compounds - metabolism Vertebrates: cardiovascular system
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Summary:	Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group. There are emerging data suggesting that S-nitrosylation of proteins plays an important role in cardioprotection. Protein S-nitrosylation not only leads to changes in protein structure and function but also prevents these thiol(s) from further irreversible oxidative/nitrosative modification. A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases.
ISSN:	0009-7330 1524-4571