Long-term outcome of isolated thrombocytopenia accompanied by hypocellular marrow

Hypocellularity of bone marrow (BM), not associated with significant dyshematopoiesis, is often found in patients with isolated thrombocytopenia, but its clinical implications have not been studied. We prospectively studied the clinical features and natural history of these patients. Adults with iso...

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Published in:Korean journal of hematology 2011-06, Vol.46 (2), p.128-134
Main Authors: Yun, Gak-Won, Yang, Young-Jun, Song, Ik-Chan, Baek, Seung-Woo, Lee, Kyu-Seop, Lee, Hyo-Jin, Yun, Hwan-Jung, Kwon, Kye-Chul, Kim, Samyong, Jo, Deog-Yeon
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Language:English
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Summary:Hypocellularity of bone marrow (BM), not associated with significant dyshematopoiesis, is often found in patients with isolated thrombocytopenia, but its clinical implications have not been studied. We prospectively studied the clinical features and natural history of these patients. Adults with isolated thrombocytopenia (platelet counts 50×10(9)/L in 16 patients (80%). BM cellularity ranged from 5% to 25% (median, 15%) and was ≤10% in 6 patients (30%). During the median 48-month follow-up (range, 12-90 months), platelet counts of 3 of the 20 patients recovered to normal levels (>150×10(9)/L) after 12, 56 and 66 months. Three patients developed pancytopenia after 11, 70 and 90 months. Two patients were consistent with moderate aplastic anemia, and 1 was confirmed as having refractory cytopenia with multilineage dysplasia. In the remainder of the patients, platelet counts remained unchanged. Isolated thrombocytopenia accompanied by hypocellular marrow encompasses a group of heterogeneous conditions.
ISSN:1738-7949
2092-9129
DOI:10.5045/kjh.2011.46.2.128