Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV

Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared...

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Bibliographic Details
Published in:Journal of clinical immunology 2005-03, Vol.25 (2), p.134-141
Main Authors: Villacres, Maria C, Literat, Oana, Degiacomo, Marina, Du, Wenbo, La Rosa, Corinna, Diamond, Don J, Kovacs, Andrea
Format: Article
Language:English
Subjects:
CD4 Antigens - metabolism
Cells, Cultured
Cytokines - metabolism
Cytomegalovirus
Female
Hepacivirus - physiology
Hepatitis C - complications
Hepatitis C - immunology
Hepatitis C - metabolism
Hepatitis C - virology
Hepatitis C virus
HIV - physiology
HIV Infections - complications
HIV Infections - immunology
HIV Infections - metabolism
HIV Infections - virology
Human immunodeficiency virus
Humans
Immunologic Memory - immunology
Male
Middle Aged
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with single HIV or HCV infection. The T helper response to HIV, HCV and cytomegalovirus (CMV) as a positive viral control was dominated by type 1 cytokines (interleukin- [IL] 2, interferon- [IFN] gamma and tumor necrosis factor- [TNF] alpha), with IFN-gamma as the most abundantly secreted. IL-4, IL-5 and IL-10 were low in healthy controls and patients. Robust CMV-specific responses contrasted with curtailed HCV-specific responses in HCV-infected women. The overall anti-viral profile was dominated by Th1 cytokines even in coinfected women but both type 1 and type 2 responses were reduced in HIV-infected women and more extensively in women with HCV/HIV coinfection.
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-005-2819-x